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metadata.dc.type: | Artigo de Periódico |
Title: | Treatment of fibrocystic disease of the breast with gestrinone, a new trienic synthetic steroid with anti-estrogen, anti-progesterone properties |
Other Titles: | International Journal of Gynecology & Obstetrics |
Authors: | Coutinho, Elsimar Metzker Boulanger, G. Azadian |
metadata.dc.creator: | Coutinho, Elsimar Metzker Boulanger, G. Azadian |
Abstract: | Coutinho EM (Maternidade Climerio de Oliveira, Department of Maternal Health, Federal University of Bahia, School of Medicine, Salvador, Bahia, Brazil), Azadian- Boulanger G (Roussel-Uclaf, Paris, France). Treatment of fibrocystic disease of the breast with Gestrinone, a new trienic synthetic steroid with anti-estrogen, anti-progesterone properties. Int J Gynaecol Obstet 22: 363-366, 1984 Twenty-eight patients with radiologically diagnosed fibrocystic disease were given twice weekly 5 mg tablets of Gestrinone, asynthetic contraceptive steroid with potent antiestrogen , anti-progesterone properties, for periods ranging from 3 to 9 months. Treatment was discontinued when the nodularity disappeared and the patient became asymptomatic. Twelve patients had palpable nodules or masses in both breasts, while the remaining 16 had a single nodule or lump. In 12patients, all with small nodules or lumps, complete elimination of nodularity occurred at the end of the first 3 months of treatment. In a further eight patients, five of whom had small nodules and three of whom had large ones, an additional 3 months of therapy were required to achieve complete elimination of nodulan’ty. In two subjects, nodularity was eliminated at the end of 9 months of therapy, and in the remaining six subjects, although a reduction in nodularity greater than 50% occurred,masses remained palpable at the end of 9 months. Pain and tenderness were eliminated during the first 2 weeks of therapy in most cases. The most common complaints were acne and seborrhea (70% of patients) and a weight gain of between 2 and 5 kg in patients treated for 9 months. Main side effects encountered were acne and seborrhea. |
Keywords: | Gestrinone Fibrocystic disease Nodularity; Steroid Mammography |
Publisher: | International Journal of Gynecology & Obstetrics |
URI: | http://www.repositorio.ufba.br/ri/handle/ri/8770 |
Issue Date: | 1984 |
Appears in Collections: | Artigo Publicado em Periódico (Faculdade de Medicina) |
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