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https://repositorio.ufba.br/handle/ri/8717
metadata.dc.type: | Artigo de Periódico |
Title: | Leishmania mexicana: Immunology and histopathology in C3H mice |
Other Titles: | Experimental Parasitology |
Authors: | Grimaldi Jr., Gabriel Moriearty, Pamela Lane |
metadata.dc.creator: | Grimaldi Jr., Gabriel Moriearty, Pamela Lane |
Abstract: | Leishmania mexicana: Immunology and histopathology in C3H mice. Experimental Parasitology 50, 45-56. C3H mice were infected subcutaneously with lo5 promastigotes of Leishmania mexicana and subsequent lesions were examined at 3, 5, and 8 months. All animals developed persistent nonulcerating nodules of variable size which did not metastasize. The nodules contained amastigotes with a mononuclear infiltrate of histiocytes, lymphocytes, and plasma cells, but without formation of tuberculoid-type granulomas. Neutrophils and eosinophils were also encountered in some cases. Specific antileishmanial antibodies and delayed-type hypersensitivity to leishmanial antigen were present at 3, 5, and 8 months postinfection. L. mexicana infection in C3H mice differs from classic self-healing cutaneous leishmaniasis by the persistence of nonhealing, nonulcerating, nonmetastasizing lesions, despite evidence of cellular and humoral immunity. |
Keywords: | Leishmania mexicana Protozoa parasitic Hemoflagellate Mice C3H Leishmaniasis cutaneous Immunofluorescence Indirect hemagglutination Delayed hypersensitivity Ear thickness test Histopathology |
Publisher: | Experimental Parasitology |
URI: | http://www.repositorio.ufba.br/ri/handle/ri/8717 |
Issue Date: | 1980 |
Appears in Collections: | Artigo Publicado em Periódico (Faculdade de Medicina) |
Files in This Item:
File | Description | Size | Format | |
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qqqqqqq7575.pdf | 2,2 MB | Adobe PDF | View/Open |
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