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metadata.dc.type: | Artigo de Periódico |
Title: | Absence of Gamma Interferon and Interleukin 2 Production during Active Visceral Leishmaniasis |
Other Titles: | Journal of Clinical Investigation |
Authors: | Carvalho Filho, Edgar Marcelino de Badaró, Roberto José da Silva |
metadata.dc.creator: | Carvalho Filho, Edgar Marcelino de Badaró, Roberto José da Silva |
Abstract: | The lymphocytes from eight patients with active visceral leishmaniasis (VL), a disease associated with marked immunologic dysfunction, were examined for ability to produce interleukin 2 (IL-2) and gamma interferon during in vitro cultivation. It was found that both IL-2 and gamma interferon production, in response to leishmania antigen, was absent during the active disease, but was restored after successful chemotherapy. Untreated VL patients produced IL-2 and gamma interferon when stimulated with phytohemagglutinin (PHA). Six patients with either active cutaneous or mucosal leishmaniasis, a disease not associated with immunosuppression, showed high levels of gamma interferon in response to leishmania antigen and PHA. Since IL-2 and gamma interferon have been shown to have important roles in the immune response and in the killing of leishmania, their absence may represent a key defect in the immune response in VL. |
Publisher: | Journal of Clinical Investigation |
URI: | http://www.repositorio.ufba.br/ri/handle/ri/8599 |
Issue Date: | 1985 |
Appears in Collections: | Artigo Publicado em Periódico (Faculdade de Medicina) |
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