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Campo DC | Valor | Idioma |
---|---|---|
dc.contributor.author | Carvalho Filho, Edgar Marcelino de | - |
dc.contributor.author | Badaró, Roberto José da Silva | - |
dc.creator | Carvalho Filho, Edgar Marcelino de | - |
dc.creator | Badaró, Roberto José da Silva | - |
dc.date.accessioned | 2013-02-21T13:21:39Z | - |
dc.date.available | 2013-02-21T13:21:39Z | - |
dc.date.issued | 1985 | - |
dc.identifier.uri | http://www.repositorio.ufba.br/ri/handle/ri/8599 | - |
dc.description | Texto completo. Acesso restrito. p. 2066-2069 | pt_BR |
dc.description.abstract | The lymphocytes from eight patients with active visceral leishmaniasis (VL), a disease associated with marked immunologic dysfunction, were examined for ability to produce interleukin 2 (IL-2) and gamma interferon during in vitro cultivation. It was found that both IL-2 and gamma interferon production, in response to leishmania antigen, was absent during the active disease, but was restored after successful chemotherapy. Untreated VL patients produced IL-2 and gamma interferon when stimulated with phytohemagglutinin (PHA). Six patients with either active cutaneous or mucosal leishmaniasis, a disease not associated with immunosuppression, showed high levels of gamma interferon in response to leishmania antigen and PHA. Since IL-2 and gamma interferon have been shown to have important roles in the immune response and in the killing of leishmania, their absence may represent a key defect in the immune response in VL. | pt_BR |
dc.language.iso | en | pt_BR |
dc.publisher | Journal of Clinical Investigation | pt_BR |
dc.source | 10.1172/JCI112209 | pt_BR |
dc.title | Absence of Gamma Interferon and Interleukin 2 Production during Active Visceral Leishmaniasis | pt_BR |
dc.title.alternative | Journal of Clinical Investigation | pt_BR |
dc.type | Artigo de Periódico | pt_BR |
dc.description.localpub | Salvador | pt_BR |
dc.identifier.number | v. 76, n.6 | pt_BR |
Aparece nas coleções: | Artigo Publicado em Periódico (Faculdade de Medicina) |
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3333.pdf | 2,21 MB | Adobe PDF | Visualizar/Abrir |
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