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metadata.dc.type: | Artigo de Periódico |
Title: | Downregulation of IFN-γ production in patients with recurrent vaginal candidiasis |
Other Titles: | Journal of Allergy and Clinical Immunology |
Authors: | Carvalho, Lucas Pedreira de Bacellar, Maria Olívia Amado Ramos Neves, Nilma Antas Jesus, Amélia Maria Ribeiro de Carvalho Filho, Edgar Marcelino de |
metadata.dc.creator: | Carvalho, Lucas Pedreira de Bacellar, Maria Olívia Amado Ramos Neves, Nilma Antas Jesus, Amélia Maria Ribeiro de Carvalho Filho, Edgar Marcelino de |
Abstract: | Background: Recurrent vaginal candidiasis (RVC) is an important health problem with unknown pathogenesis. Although impairment of the T-cell response is associated with persistent or recurrent candidiasis, data on immunologic responses in patients with RVC are controversial. Objectives: To evaluate the T-cell response in patients with RVC and the ability of cytokines and cytokine antagonists to modulate IFN-γ production in cultures stimulated with Candida albicans antigens. Methods: Participants in the study included 13 patients with RVC and 7 control women with sporadic candidiasis. Cytokines were determined by ELISA in supernatants of mononuclear cells with C albicans , purified protein derivative, or tetanus toxoid antigen. Results: IFN-γ production was absent or low in 11 of 13 women (84.6%) with RVC. Absent or low IFN-γ production was specific to C albicans antigens (189 ± 389 pg/mL), because high IFN-γ levels were found in cultures stimulated with purified protein derivative (739 ± 774 pg/mL) or tetanus toxoid antigens (1085 ± 546 pg/mL). Monoclonal antibody anti-IL-10 enhanced IFN-γ levels (750 ± 753 pg/mL), and IL-10 suppressed this cytokine production in patients with sporadic candidiasis. Conclusions: Mononuclear cells from patients with RVC stimulated with C albicans antigen have low or absent IFN-γ production. IL-10 plays an important role in downregulation of the T-cell response in these patients. (J Allergy Clin Immunol 2002;109:102-5.) |
Keywords: | Recurrent vaginal candidiasis cytokines immune regulation |
URI: | http://www.repositorio.ufba.br/ri/handle/ri/7595 |
Issue Date: | Jan-2002 |
Appears in Collections: | Artigo Publicado em Periódico (ICS) |
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