Por favor, use este identificador para citar o enlazar este ítem:
https://repositorio.ufba.br/handle/ri/5949
metadata.dc.type: | Artigo de Periódico |
Título : | Effect of oral contraceptives on vascular endothelial growth factor, Cox-2 and aromatase expression in the endometrium of uteri affected by myomas and associated pathologies |
Otros títulos : | Contraception |
Autor : | Maia Junior, Hugo Casoy, Julio Pimentel, Kleber Santos Correia, Tania Athayde, Célia Maria Soares Cruz, Thomaz Rodrigues Porto da Coutinho, Elsimar Metzker |
metadata.dc.creator: | Maia Junior, Hugo Casoy, Julio Pimentel, Kleber Santos Correia, Tania Athayde, Célia Maria Soares Cruz, Thomaz Rodrigues Porto da Coutinho, Elsimar Metzker |
Resumen : | Background: The study was conducted to evaluate vascular endothelial growth factor (VEGF), Cox-2 and aromatase expression in the endometrium of uteri with myomas and other associated pathologies. Study Design: Hysteroscopy was performed in 118 women of reproductive age with myomas and menorrhagia, 40 of whom were using a pill containing 75 mcg gestodene+30 mcg ethinylestradiol. Aromatase p450, VEGF and Cox-2 expression was detected using immunohistochemistry. Fisher's Exact Test and the Mann–Whitney test were used in the statistical analysis, with significance established at pb.05. Results: In patients with myomas and menorrhagia, associated pathologies such as adenomyosis, endometrial polyps and endometriosis were found in 32%, 12% and 17% of cases, respectively. Aromatase, Cox-2 and VEGF expression was greater during the proliferative phase compared to the luteal phase of the cycle or following oral contraceptive use. Conclusion: Endogenous progesterone or combined oral contraceptives are potent inhibitors of VEGF, aromatase and Cox-2 expression in the endometrium of patients with myomas and menorrhagia. © 2008 Elsevier Inc. All rights reserved. |
Palabras clave : | Gestodene VEGF Aromatase Cox-2 Myoma Menorrhagia |
URI : | http://www.repositorio.ufba.br/ri/handle/ri/5949 |
Fecha de publicación : | 2008 |
Aparece en las colecciones: | Artigo Publicado em Periódico (Faculdade de Medicina) |
Ficheros en este ítem:
Fichero | Descripción | Tamaño | Formato | |
---|---|---|---|---|
__ac.els-cdn.com_S001078...0301810acfa88fb02630e508e51d6.pdf Restricted Access | 283,44 kB | Adobe PDF | Visualizar/Abrir Request a copy |
Los ítems de DSpace están protegidos por copyright, con todos los derechos reservados, a menos que se indique lo contrario.