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Campo DC | Valor | Idioma |
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dc.contributor.author | Maia Junior, Hugo | - |
dc.contributor.author | Casoy, Julio | - |
dc.contributor.author | Pimentel, Kleber Santos | - |
dc.contributor.author | Correia, Tania | - |
dc.contributor.author | Athayde, Célia Maria Soares | - |
dc.contributor.author | Cruz, Thomaz Rodrigues Porto da | - |
dc.contributor.author | Coutinho, Elsimar Metzker | - |
dc.creator | Maia Junior, Hugo | - |
dc.creator | Casoy, Julio | - |
dc.creator | Pimentel, Kleber Santos | - |
dc.creator | Correia, Tania | - |
dc.creator | Athayde, Célia Maria Soares | - |
dc.creator | Cruz, Thomaz Rodrigues Porto da | - |
dc.creator | Coutinho, Elsimar Metzker | - |
dc.date.accessioned | 2012-05-24T13:29:01Z | - |
dc.date.issued | 2008 | - |
dc.identifier.issn | 0010-7824 | - |
dc.identifier.uri | http://www.repositorio.ufba.br/ri/handle/ri/5949 | - |
dc.description | Acesso restrito: Texto completo. p. 479-485 | pt_BR |
dc.description.abstract | Background: The study was conducted to evaluate vascular endothelial growth factor (VEGF), Cox-2 and aromatase expression in the endometrium of uteri with myomas and other associated pathologies. Study Design: Hysteroscopy was performed in 118 women of reproductive age with myomas and menorrhagia, 40 of whom were using a pill containing 75 mcg gestodene+30 mcg ethinylestradiol. Aromatase p450, VEGF and Cox-2 expression was detected using immunohistochemistry. Fisher's Exact Test and the Mann–Whitney test were used in the statistical analysis, with significance established at pb.05. Results: In patients with myomas and menorrhagia, associated pathologies such as adenomyosis, endometrial polyps and endometriosis were found in 32%, 12% and 17% of cases, respectively. Aromatase, Cox-2 and VEGF expression was greater during the proliferative phase compared to the luteal phase of the cycle or following oral contraceptive use. Conclusion: Endogenous progesterone or combined oral contraceptives are potent inhibitors of VEGF, aromatase and Cox-2 expression in the endometrium of patients with myomas and menorrhagia. © 2008 Elsevier Inc. All rights reserved. | pt_BR |
dc.language.iso | en | pt_BR |
dc.source | http://dx.doi.org/10.1016/j.contraception.2008.07.002 | pt_BR |
dc.subject | Gestodene | pt_BR |
dc.subject | VEGF | pt_BR |
dc.subject | Aromatase | pt_BR |
dc.subject | Cox-2 | pt_BR |
dc.subject | Myoma | pt_BR |
dc.subject | Menorrhagia | pt_BR |
dc.title | Effect of oral contraceptives on vascular endothelial growth factor, Cox-2 and aromatase expression in the endometrium of uteri affected by myomas and associated pathologies | pt_BR |
dc.title.alternative | Contraception | pt_BR |
dc.type | Artigo de Periódico | pt_BR |
dc.identifier.number | v. 78, n. 6 | pt_BR |
dc.embargo.liftdate | 10000-01-01 | - |
Aparece nas coleções: | Artigo Publicado em Periódico (Faculdade de Medicina) |
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