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https://repositorio.ufba.br/handle/ri/5281
metadata.dc.type: | Artigo de Periódico |
Title: | Thyroid disorders in patients with chronic hepatitis C using interferon-alpha and ribavirin therapy |
Other Titles: | SciELO - Scientific Electronic Library Online |
Authors: | Andrade, Luis Jesuino de Oliveira Atta, Ajax Mercês Atta, Maria Luiza Brito de Sousa Mangabeira, Célia Neder Kalil Paraná, Raymundo |
metadata.dc.creator: | Andrade, Luis Jesuino de Oliveira Atta, Ajax Mercês Atta, Maria Luiza Brito de Sousa Mangabeira, Célia Neder Kalil Paraná, Raymundo |
Abstract: | OBJECTIVE: To investigate the frequency of thyroid disorders (TD) in patients with chronic hepatitis C before and during interferon-alpha (IFN-α) and ribavirin (RIB) treatment. STUDY DESIGN: Prospective study. PATIENTS AND METHODS: We prospectively studied 65 anti-HCV and viral RNA positive patients. Free thyroxine, thyroid-stimulating hormone, and thyroid peroxidase antibodies (TPO-Ab) were systematically tested at entry (m0), week 12 (m3) and week 24 (m6) of treatment. RESULTS: Mean age of the 65 patients (38 females and 27 males) was 49.61 ± 11.83 years. Seven (10.76%) patients presented baseline thyroid disorders (m0), three had thyroid dysfunction, and four were TPO-Ab positive. Thyroid disorders occurred in the first 12 weeks of treatment in 11 (16.92%) patients, four with thyroid dysfunction, and seven with TPO-Ab positive (m3). A total of 18 patients (27.69%) developed TD after 24 weeks of treatment, 7 with thyroid dysfunction, and 11 with TPO-Ab positive (m6). The relative risk of developing hypothyroidism found in this study was 1.3 (95% CI: 1.1 to 1.6), hyperthyroidism 1.2 (95% CI: 1.1 to 1.4), and TPO-Ab positivity 7.6 (95% CI: 3.9 to 14.5). The study showed a significant association between female sex and thyroid disease (p = 0.009). CONCLUSION: Thyroid dysfunction and autoimmune TD were observed during IFN-α and RIB therapy. |
Keywords: | hepatitis C interferon-alpha ribavirin thyroid diseases autoimmunity |
URI: | http://www.repositorio.ufba.br/ri/handle/ri/5281 |
Issue Date: | 2010 |
Appears in Collections: | Artigo Publicado em Periódico (Faculdade de Medicina) |
Files in This Item:
File | Description | Size | Format | |
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v15n4a13.pdf | 938,66 kB | Adobe PDF | View/Open |
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