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Use este identificador para citar ou linkar para este item: https://repositorio.ufba.br/handle/ri/5281
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dc.contributor.authorAndrade, Luis Jesuino de Oliveira-
dc.contributor.authorAtta, Ajax Mercês-
dc.contributor.authorAtta, Maria Luiza Brito de Sousa-
dc.contributor.authorMangabeira, Célia Neder Kalil-
dc.contributor.authorParaná, Raymundo-
dc.creatorAndrade, Luis Jesuino de Oliveira-
dc.creatorAtta, Ajax Mercês-
dc.creatorAtta, Maria Luiza Brito de Sousa-
dc.creatorMangabeira, Célia Neder Kalil-
dc.creatorParaná, Raymundo-
dc.date.accessioned2012-01-30T17:45:29Z-
dc.date.issued2010-
dc.identifier.issn1413-8670-
dc.identifier.urihttp://www.repositorio.ufba.br/ri/handle/ri/5281-
dc.descriptionp. 377-381.pt_BR
dc.description.abstractOBJECTIVE: To investigate the frequency of thyroid disorders (TD) in patients with chronic hepatitis C before and during interferon-alpha (IFN-α) and ribavirin (RIB) treatment. STUDY DESIGN: Prospective study. PATIENTS AND METHODS: We prospectively studied 65 anti-HCV and viral RNA positive patients. Free thyroxine, thyroid-stimulating hormone, and thyroid peroxidase antibodies (TPO-Ab) were systematically tested at entry (m0), week 12 (m3) and week 24 (m6) of treatment. RESULTS: Mean age of the 65 patients (38 females and 27 males) was 49.61 ± 11.83 years. Seven (10.76%) patients presented baseline thyroid disorders (m0), three had thyroid dysfunction, and four were TPO-Ab positive. Thyroid disorders occurred in the first 12 weeks of treatment in 11 (16.92%) patients, four with thyroid dysfunction, and seven with TPO-Ab positive (m3). A total of 18 patients (27.69%) developed TD after 24 weeks of treatment, 7 with thyroid dysfunction, and 11 with TPO-Ab positive (m6). The relative risk of developing hypothyroidism found in this study was 1.3 (95% CI: 1.1 to 1.6), hyperthyroidism 1.2 (95% CI: 1.1 to 1.4), and TPO-Ab positivity 7.6 (95% CI: 3.9 to 14.5). The study showed a significant association between female sex and thyroid disease (p = 0.009). CONCLUSION: Thyroid dysfunction and autoimmune TD were observed during IFN-α and RIB therapy.pt_BR
dc.language.isoenpt_BR
dc.sourcehttp://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702011000400013&lng=en&nrm=iso&tlng=enpt_BR
dc.subjecthepatitis Cpt_BR
dc.subjectinterferon-alphapt_BR
dc.subjectribavirinpt_BR
dc.subjectthyroid diseasespt_BR
dc.subjectautoimmunitypt_BR
dc.titleThyroid disorders in patients with chronic hepatitis C using interferon-alpha and ribavirin therapypt_BR
dc.title.alternativeSciELO - Scientific Electronic Library Onlinept_BR
dc.typeArtigo de Periódicopt_BR
dc.description.localpubSalvadorpt_BR
dc.identifier.numberv. 15, n. 4.pt_BR
dc.embargo.liftdate10000-01-01-
Aparece nas coleções:Artigo Publicado em Periódico (Faculdade de Medicina)

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