Por favor, use este identificador para citar o enlazar este ítem:
https://repositorio.ufba.br/handle/ri/20785
metadata.dc.type: | Artigo de Periódico |
Título : | Oxidative stress in neurodegenerative diseases: Mechanisms and therapeutic perspectives |
Autor : | Melo, Ailton de Souza Monteiro, Larissa Lima, Rute Maria Ferreira Oliveira, Diêgo Madureira de Cerqueira, Martins Dias de El-Bachá, Ramon dos Santos |
metadata.dc.creator: | Melo, Ailton de Souza Monteiro, Larissa Lima, Rute Maria Ferreira Oliveira, Diêgo Madureira de Cerqueira, Martins Dias de El-Bachá, Ramon dos Santos |
Resumen : | The incidence and prevalence of neurodegenerative diseases (ND) increase with life expectancy. This paper reviews the role of oxidative stress (OS) in ND and pharmacological attempts to fight against reactive oxygen species (ROS)-induced neurodegeneration. Several mechanisms involved in ROS generation in neurodegeneration have been proposed. Recent articles about molecular pathways involved in ROS generation were reviewed. The progress in the development of neuroprotective therapies has been hampered because it is difficult to define targets for treatment and determine what should be considered as neuroprotective. Therefore, the attention was focused on researches about pharmacological targets that could protect neurons against OS. Since it is necessary to look for genes as the ultimate controllers of all biological processes, this paper also tried to identify gerontogenes involved in OS and neurodegeneration. Since neurons depend on glial cells to survive, recent articles about the functioning of these cells in aging and ND were also reviewed. Finally, clinical trials testing potential neuroprotective agents were critically reviewed. Although several potential drugs have been screened in in vitro and in vivo models of ND, these results were not translated in benefit of patients, and disappointing results were obtained in the majority of clinical trials. |
Palabras clave : | Oxidative Stress Neurodegenerative Diseases Therapeutic Perspectives |
Editorial : | Hindawi Publishing Corporation |
Citación : | Melo e col., 2011 |
metadata.dc.rights: | Acesso Aberto |
URI : | http://repositorio.ufba.br/ri/handle/ri/20785 |
Fecha de publicación : | 2011 |
Aparece en las colecciones: | Artigo Publicado em Periódico (ICS) |
Ficheros en este ítem:
Fichero | Descripción | Tamaño | Formato | |
---|---|---|---|---|
Melo et al 2011.pdf | 2,67 MB | Adobe PDF | Visualizar/Abrir |
Los ítems de DSpace están protegidos por copyright, con todos los derechos reservados, a menos que se indique lo contrario.