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https://repositorio.ufba.br/handle/ri/19049
metadata.dc.type: | Artigo de Periódico |
Title: | Effectiveness of Meningococcal C conjugate vaccine in Salvador, Brazil: a case-control study. |
Other Titles: | PLoS One |
Authors: | Cardoso, Cristiane Wanderley Ribeiro, Guilherme Sousa Reis, Mitermayer Galvão Flannery, Brendan Reis, Joice Neves |
metadata.dc.creator: | Cardoso, Cristiane Wanderley Ribeiro, Guilherme Sousa Reis, Mitermayer Galvão Flannery, Brendan Reis, Joice Neves |
Abstract: | During a citywide epidemic of serogroup C meningococcal disease in Salvador in 2010, Brazil, the state government initiated mass vaccination targeting two age groups with high attack rates: individuals aged <5 years and 10–24 years. More than 600,000 doses of meningococcal serogroup C conjugate vaccines were administered. We performed a casecontrol study to evaluate vaccine uptake, document vaccine effectiveness and identify reasons for non-vaccination. Methods and Findings Population-based surveillance identified patients with laboratory-confirmed invasive meningococcal C (MenC) disease during 2010. Information on MenC vaccination was obtained from case patients and age-matched individuals from the same neighborhoods. MenC vaccine effectiveness was estimated based on the exact odds ratios obtained by conditional logistic regression analysis. Of 51 laboratory-confirmed cases of serogroup C meningococcal disease among patients <5 and 10–24 years of age 50 were included in the study and matched with 240 controls. Overall case-fatality was 25%.MenC vaccine coverage among controls increased from 7.1%to 70.2% after initiation of the vaccination campaign. None of the 50 case patients but 70 (29.2%) of the 240 control individuals, including 59 (70.2%) of 84 matched with cases from the period afterMenC vaccination, had received at least one MenC vaccine dose. Overall effectiveness of MenC was 98%with a lower 95%exact confidence limit of 89%. Conclusions MenC vaccines administered during the meningococcal epidemic were highly effective, suggesting that rapid vaccine uptake through campaigns contributed to control of meningococcal disease. |
Keywords: | Meningococcal Disease Meningococcal Vaccine Epidemic |
metadata.dc.publisher.country: | Brasil |
Publisher: | Public Library of Science |
metadata.dc.rights: | Acesso Aberto |
URI: | http://repositorio.ufba.br/ri/handle/ri/19049 |
Issue Date: | Apr-2015 |
Appears in Collections: | Artigo Publicado em Periódico Estrangeiro (ISC) |
Files in This Item:
File | Description | Size | Format | |
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Art Per Estrang Guilherme Ribeiro3. 2015.pdf | 188,33 kB | Adobe PDF | View/Open |
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