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https://repositorio.ufba.br/handle/ri/13660
metadata.dc.type: | Artigo de Periódico |
Título : | Role of 5-HT3 and 5-HT2C receptors located within the medial amygdala in the control of salt intake in sodium-depleted rats |
Otros títulos : | Brain Research |
Autor : | Souza, Anderson Reis, Rodolfo Fregoneze, Josmara Bartolomei Castro e Silva, Emilio de |
metadata.dc.creator: | Souza, Anderson Reis, Rodolfo Fregoneze, Josmara Bartolomei Castro e Silva, Emilio de |
Resumen : | In the present study, we investigated the role of 5-HT3 and 5-HT2C receptors located within the medial amygdala (MeA) in the control of water and salt intake in sodium-depleted rats. Pharmacological activation of 5-HT3 receptors located in the medial amygdala by the selective 5-HT3 receptor agonist m-CPBG significantly reduced salt intake in sodium-depleted rats, an effect that is reverted by pretreatment with the selective 5-HT3 receptor antagonist ondansetron. In addition, the injection of ondansetron alone into the medial amygdala had no effect on salt intake in sodium-depleted and in sodium-repleted rats. Pharmacological stimulation of 5-HT2C receptors located in the medial amygdala by the selective 5-HT2C receptor agonist m-CPP failed to modify salt intake in sodium-depleted rats, whereas the blockade of these receptors by the selective 5-HT2C receptor antagonist SDZ SER 082 significantly reduced salt intake in this same group of animals. These results lead to the conclusion that the pharmacological activation of 5-HT3 receptors located within the MeA inhibits salt intake in sodium-depleted rats and that, in this same brain region, the functional integrity of 5-HT2C receptors is required to achieve the full expression of sodium appetite in sodium-depleted rats. |
Palabras clave : | m-CPP Serotonin 5-HT2C receptor m-CPBG 5-HT3 receptor Salt intake |
metadata.dc.rights: | Acesso Aberto |
URI : | http://repositorio.ufba.br/ri/handle/ri/13660 |
Fecha de publicación : | 2006 |
Aparece en las colecciones: | Artigo Publicado em Periódico (ICS) |
Ficheros en este ítem:
Fichero | Descripción | Tamaño | Formato | |
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1-s2.0-S0006899306012169-main.pdf | 346,17 kB | Adobe PDF | Visualizar/Abrir |
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