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Campo DC | Valor | Idioma |
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dc.contributor.author | Souza, Anderson | - |
dc.contributor.author | Reis, Rodolfo | - |
dc.contributor.author | Fregoneze, Josmara Bartolomei | - |
dc.contributor.author | Castro e Silva, Emilio de | - |
dc.creator | Souza, Anderson | - |
dc.creator | Reis, Rodolfo | - |
dc.creator | Fregoneze, Josmara Bartolomei | - |
dc.creator | Castro e Silva, Emilio de | - |
dc.date.accessioned | 2013-11-16T12:36:53Z | - |
dc.date.issued | 2006 | - |
dc.identifier.issn | 0006-8993 | - |
dc.identifier.uri | http://repositorio.ufba.br/ri/handle/ri/13660 | - |
dc.description | Texto completo: acesso restrito. p.121–132 | pt_BR |
dc.description.abstract | In the present study, we investigated the role of 5-HT3 and 5-HT2C receptors located within the medial amygdala (MeA) in the control of water and salt intake in sodium-depleted rats. Pharmacological activation of 5-HT3 receptors located in the medial amygdala by the selective 5-HT3 receptor agonist m-CPBG significantly reduced salt intake in sodium-depleted rats, an effect that is reverted by pretreatment with the selective 5-HT3 receptor antagonist ondansetron. In addition, the injection of ondansetron alone into the medial amygdala had no effect on salt intake in sodium-depleted and in sodium-repleted rats. Pharmacological stimulation of 5-HT2C receptors located in the medial amygdala by the selective 5-HT2C receptor agonist m-CPP failed to modify salt intake in sodium-depleted rats, whereas the blockade of these receptors by the selective 5-HT2C receptor antagonist SDZ SER 082 significantly reduced salt intake in this same group of animals. These results lead to the conclusion that the pharmacological activation of 5-HT3 receptors located within the MeA inhibits salt intake in sodium-depleted rats and that, in this same brain region, the functional integrity of 5-HT2C receptors is required to achieve the full expression of sodium appetite in sodium-depleted rats. | pt_BR |
dc.language.iso | en | pt_BR |
dc.rights | Acesso Aberto | pt_BR |
dc.source | http://dx.doi.org.ez10.periodicos.capes.gov.br/10.1016/j.brainres.2006.04.083 | pt_BR |
dc.subject | m-CPP | pt_BR |
dc.subject | Serotonin | pt_BR |
dc.subject | 5-HT2C receptor | pt_BR |
dc.subject | m-CPBG | pt_BR |
dc.subject | 5-HT3 receptor | pt_BR |
dc.subject | Salt intake | pt_BR |
dc.title | Role of 5-HT3 and 5-HT2C receptors located within the medial amygdala in the control of salt intake in sodium-depleted rats | pt_BR |
dc.title.alternative | Brain Research | pt_BR |
dc.type | Artigo de Periódico | pt_BR |
dc.identifier.number | v.1099, n. 1 | pt_BR |
dc.embargo.liftdate | 10000-01-01 | - |
Aparece nas coleções: | Artigo Publicado em Periódico (ICS) |
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1-s2.0-S0006899306012169-main.pdf | 346,17 kB | Adobe PDF | Visualizar/Abrir |
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