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https://repositorio.ufba.br/handle/ri/7855
metadata.dc.type: | Artigo de Periódico |
Título : | Human immune responses to Schistosoma mansoni vaccine candidate antigens |
Otros títulos : | Infection and Immunity |
Autor : | Jesus, Amélia Ribeiro de Araújo, Ilma Bacellar, Maria Olívia Amado Ramos Magalhães, Andréa Pearce, Edward Harn, Donald Strand, Mette Carvalho Filho, Edgar Marcelino de |
metadata.dc.creator: | Jesus, Amélia Ribeiro de Araújo, Ilma Bacellar, Maria Olívia Amado Ramos Magalhães, Andréa Pearce, Edward Harn, Donald Strand, Mette Carvalho Filho, Edgar Marcelino de |
Resumen : | To determine the naturally occurring immunological responses to theSchistosoma mansoni antigens paramyosin, IrV-5, Sm-23 (MAP-3), and triose phosphate isomerase (MAP-4), a total of 119 subjects from an area of endemicity for schistosomiasis, including “resistant” subjects (n = 17) were evaluated. Specific immunoglobulin G1 (IgG1), IgG2, IgG3, IgG4, and IgA levels for each of the antigens and the cytokine profile in culture supernatants from antigen-stimulated peripheral blood mononuclear cells (PBMC) were determined. Although all the subjects had a high degree of contaminated water exposure, their infection levels were variable (0 to 1,128 eggs/g of stool). There were direct correlations between infection levels and levels of SWAP- and paramyosin-specific IgG1 and IgG4 (P < 0.05). However, an inverse correlation between infection levels and specific IgG2 to IrV-5 (P < 0.01) was observed. The evaluation of the cytokine profile (interleukin 5 [IL-5], IL-10, gamma interferon [IFN-γ], and tumor necrosis factor alpha) in response to these antigens showed inverse correlations between the degree of infection and IFN-γ levels in PBMC supernatants stimulated with paramyosin (P < 0.05) and IrV-5 (P < 0.01). Additionally, inverse correlations between the degree of infection and IL-5 levels in MAP-3- and MAP-4-stimulated PBMC supernatants (P < 0.01) were found. Logistic regression analysis was performed to adjust the results of cytokine profile by age. IL-5 production in MAP-3-stimulated PBMC supernatants was associated with lower infection levels (odds ratio = 11.2 [95% confidence interval, 2.7 to 45.8]). |
URI : | http://www.repositorio.ufba.br/ri/handle/ri/7855 |
Fecha de publicación : | may-2000 |
Aparece en las colecciones: | Artigo Publicado em Periódico (EMV) |
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Fichero | Descripción | Tamaño | Formato | |
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Jesus.pdf Restricted Access | 183,33 kB | Adobe PDF | Visualizar/Abrir Request a copy |
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