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Campo DC | Valor | Idioma |
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dc.contributor.author | Jesus, Amélia Ribeiro de | - |
dc.contributor.author | Araújo, Ilma | - |
dc.contributor.author | Bacellar, Maria Olívia Amado Ramos | - |
dc.contributor.author | Magalhães, Andréa | - |
dc.contributor.author | Pearce, Edward | - |
dc.contributor.author | Harn, Donald | - |
dc.contributor.author | Strand, Mette | - |
dc.contributor.author | Carvalho Filho, Edgar Marcelino de | - |
dc.creator | Jesus, Amélia Ribeiro de | - |
dc.creator | Araújo, Ilma | - |
dc.creator | Bacellar, Maria Olívia Amado Ramos | - |
dc.creator | Magalhães, Andréa | - |
dc.creator | Pearce, Edward | - |
dc.creator | Harn, Donald | - |
dc.creator | Strand, Mette | - |
dc.creator | Carvalho Filho, Edgar Marcelino de | - |
dc.date.accessioned | 2013-01-15T10:43:43Z | - |
dc.date.issued | 2000-05 | - |
dc.identifier.issn | 0019-9567 | - |
dc.identifier.uri | http://www.repositorio.ufba.br/ri/handle/ri/7855 | - |
dc.description | Texto completo: acesso restrito. p. 2797-2803 | pt_BR |
dc.description.abstract | To determine the naturally occurring immunological responses to theSchistosoma mansoni antigens paramyosin, IrV-5, Sm-23 (MAP-3), and triose phosphate isomerase (MAP-4), a total of 119 subjects from an area of endemicity for schistosomiasis, including “resistant” subjects (n = 17) were evaluated. Specific immunoglobulin G1 (IgG1), IgG2, IgG3, IgG4, and IgA levels for each of the antigens and the cytokine profile in culture supernatants from antigen-stimulated peripheral blood mononuclear cells (PBMC) were determined. Although all the subjects had a high degree of contaminated water exposure, their infection levels were variable (0 to 1,128 eggs/g of stool). There were direct correlations between infection levels and levels of SWAP- and paramyosin-specific IgG1 and IgG4 (P < 0.05). However, an inverse correlation between infection levels and specific IgG2 to IrV-5 (P < 0.01) was observed. The evaluation of the cytokine profile (interleukin 5 [IL-5], IL-10, gamma interferon [IFN-γ], and tumor necrosis factor alpha) in response to these antigens showed inverse correlations between the degree of infection and IFN-γ levels in PBMC supernatants stimulated with paramyosin (P < 0.05) and IrV-5 (P < 0.01). Additionally, inverse correlations between the degree of infection and IL-5 levels in MAP-3- and MAP-4-stimulated PBMC supernatants (P < 0.01) were found. Logistic regression analysis was performed to adjust the results of cytokine profile by age. IL-5 production in MAP-3-stimulated PBMC supernatants was associated with lower infection levels (odds ratio = 11.2 [95% confidence interval, 2.7 to 45.8]). | pt_BR |
dc.language.iso | en | pt_BR |
dc.source | http://dx.doi.org/10.1128/IAI.68.5.2797-2803.2000 | pt_BR |
dc.title | Human immune responses to Schistosoma mansoni vaccine candidate antigens | pt_BR |
dc.title.alternative | Infection and Immunity | pt_BR |
dc.type | Artigo de Periódico | pt_BR |
dc.identifier.number | v. 68, n. 5 | pt_BR |
dc.embargo.liftdate | 10000-01-01 | - |
Aparece nas coleções: | Artigo Publicado em Periódico (EMV) |
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