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https://repositorio.ufba.br/handle/ri/7192
metadata.dc.type: | Artigo de Periódico |
Title: | HTLV-1 modifies the clinical and immunological response to schistosomiasis |
Other Titles: | Clinical and Experimental Immunology |
Authors: | Porto, Maria Aurélia da Fonseca Santos, S. B. Alcântara, Leda Maria Guerreiro, J. B. Passos, J. Gonzalez, T. Neva, Franklin A. Gonzalez, D. |
metadata.dc.creator: | Porto, Maria Aurélia da Fonseca Santos, S. B. Alcântara, Leda Maria Guerreiro, J. B. Passos, J. Gonzalez, T. Neva, Franklin A. Gonzalez, D. |
Abstract: | The immunological response in HTLV-1 infected individuals is characterized by a prominent Type-1 cytokine response with high production of IFNg and TNFa. In contrast, helminthic infections and in particular chronic schistosomiasis are associated with a predominant production of IL-4, IL-5, IL-10 and IL-13. Liver fibrosis is the main pathological finding in schistosomiasis that occurs after many years of infection. This pathology is T cell dependent but the immune response mechanisms are not completely understood. The North-east region of Brazil is endemic for both HTLV-1 and schistosomiasis. In the present study the immune response, clinical severity, and therapeutic response to praziquantel of patients with schistosomiasis coinfected with HTLV-1 were compared with patients infected only with S. mansoni. Patients with HTLV-1 and S.mansoni had lower levels of IL-5 (P<0·05) and higher levelsof (P<0·05) in cultures stimulated with S. manson antigen and decreased S. mansoni antigen specific IgE levels when compared with patients with schistosomiasis without HTLV-1 coinfection. Liver fibrosis was mild in all HTLV-1 coinfected patients and efficacy of praziquantel was lower in patients dually infected than in patients infected only with S. mansoni. |
Keywords: | HTLV-1 schistosomiasis liver fibrosis |
Publisher: | Elsevier |
URI: | http://www.repositorio.ufba.br/ri/handle/ri/7192 |
Issue Date: | 2004 |
Appears in Collections: | Artigo Publicado em Periódico (Faculdade de Medicina) |
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CONFIG~1....1365-2249.2004.02508.x-1.pdf Restricted Access | 65,28 kB | Adobe PDF | View/Open Request a copy |
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