https://repositorio.ufba.br/handle/ri/7192
Campo DC | Valor | Idioma |
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dc.contributor.author | Porto, Maria Aurélia da Fonseca | - |
dc.contributor.author | Santos, S. B. | - |
dc.contributor.author | Alcântara, Leda Maria | - |
dc.contributor.author | Guerreiro, J. B. | - |
dc.contributor.author | Passos, J. | - |
dc.contributor.author | Gonzalez, T. | - |
dc.contributor.author | Neva, Franklin A. | - |
dc.contributor.author | Gonzalez, D. | - |
dc.creator | Porto, Maria Aurélia da Fonseca | - |
dc.creator | Santos, S. B. | - |
dc.creator | Alcântara, Leda Maria | - |
dc.creator | Guerreiro, J. B. | - |
dc.creator | Passos, J. | - |
dc.creator | Gonzalez, T. | - |
dc.creator | Neva, Franklin A. | - |
dc.creator | Gonzalez, D. | - |
dc.date.accessioned | 2012-11-13T13:29:28Z | - |
dc.date.issued | 2004 | - |
dc.identifier.issn | 0009-9104 | - |
dc.identifier.uri | http://www.repositorio.ufba.br/ri/handle/ri/7192 | - |
dc.description | p. 424-429 | pt_BR |
dc.description.abstract | The immunological response in HTLV-1 infected individuals is characterized by a prominent Type-1 cytokine response with high production of IFNg and TNFa. In contrast, helminthic infections and in particular chronic schistosomiasis are associated with a predominant production of IL-4, IL-5, IL-10 and IL-13. Liver fibrosis is the main pathological finding in schistosomiasis that occurs after many years of infection. This pathology is T cell dependent but the immune response mechanisms are not completely understood. The North-east region of Brazil is endemic for both HTLV-1 and schistosomiasis. In the present study the immune response, clinical severity, and therapeutic response to praziquantel of patients with schistosomiasis coinfected with HTLV-1 were compared with patients infected only with S. mansoni. Patients with HTLV-1 and S.mansoni had lower levels of IL-5 (P<0·05) and higher levelsof (P<0·05) in cultures stimulated with S. manson antigen and decreased S. mansoni antigen specific IgE levels when compared with patients with schistosomiasis without HTLV-1 coinfection. Liver fibrosis was mild in all HTLV-1 coinfected patients and efficacy of praziquantel was lower in patients dually infected than in patients infected only with S. mansoni. | pt_BR |
dc.language.iso | en | pt_BR |
dc.publisher | Elsevier | pt_BR |
dc.source | http://onlinelibrary.wiley.com/doi/10.1111/j.1365-2249.2004.02508.x/pdf | pt_BR |
dc.subject | HTLV-1 | pt_BR |
dc.subject | schistosomiasis | pt_BR |
dc.subject | liver fibrosis | pt_BR |
dc.title | HTLV-1 modifies the clinical and immunological response to schistosomiasis | pt_BR |
dc.title.alternative | Clinical and Experimental Immunology | pt_BR |
dc.type | Artigo de Periódico | pt_BR |
dc.identifier.number | v. 137, n. 2 | pt_BR |
dc.embargo.liftdate | 10000-01-01 | - |
Aparece nas coleções: | Artigo Publicado em Periódico (Faculdade de Medicina) |
Arquivo | Descrição | Tamanho | Formato | |
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CONFIG~1....1365-2249.2004.02508.x-1.pdf Restricted Access | 65,28 kB | Adobe PDF | Visualizar/Abrir Solicitar uma cópia |
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