Please use this identifier to cite or link to this item:
https://repositorio.ufba.br/handle/ri/5768
metadata.dc.type: | Artigo de Periódico |
Title: | Seropositivity to anti-phenolic glycolipid-I in leprosy cases, contacts and no known contacts of leprosy in an endemic and a non-endemic area in northeast Brazil |
Other Titles: | Transactions of the Royal Society of Tropical Medicine and Hygiene |
Authors: | Frota, Cristiane C. Freitas, Max V. C. Foss, Norma T. Lima, Luana Nepomuceno Costa Rodrigues, Laura C. Barreto, Mauricio Lima Kerr, Ligia Regina Franco Sansigolo |
metadata.dc.creator: | Frota, Cristiane C. Freitas, Max V. C. Foss, Norma T. Lima, Luana Nepomuceno Costa Rodrigues, Laura C. Barreto, Mauricio Lima Kerr, Ligia Regina Franco Sansigolo |
Abstract: | The seroprevalence rates of IgM anti-phenolic glycolipid-I (PGL-I) antibodies in four study groups with differing exposure to Mycobacterium leprae in Ceará, Brazil were investigated between March 2005 and August 2006. The first three groups in a high prevalence area included 144 cases of leprosy, their 380 contacts and 317 participants with no known leprosy contact. The fourth group in a low prevalence area consisted of 87 participants with no known leprosy contact living in an area in which no cases of leprosy had been reported in the previous 6 months. Seropositivity and levels of IgM antibodies to PGL-I were investigated using ELISA. The seropositivity levels of anti-PGL-I among the different clinical forms of leprosy cases were 61% for lepromatous, 25% for tuberculoid and 27% indeterminate. The levels of anti-PGL-I antibodies in the endemic area differentiated leprosy cases from noncases. However, the seropositivity was similar among contact cases (15.8%) and no known leprosy contact cases from high (15.1%) and low (13.8%) prevalence areas. The seropositivity of both contacts and no known contacts was much higher than previously reported among no known contacts in other endemic areas. The study indicates that anti-PGL-I antibodies are not useful as immunological markers of household leprosy contacts and no known leprosy contacts in endemic areas. |
Keywords: | Leprosy Mycobacterium leprae Seroprevalence Immunologic marker Phenolic glycolipid-I Brazil |
URI: | http://www.repositorio.ufba.br/ri/handle/ri/5768 |
Issue Date: | 2010 |
Appears in Collections: | Artigo Publicado em Periódico (Faculdade de Medicina) |
Files in This Item:
File | Description | Size | Format | |
---|---|---|---|---|
__ac.els-cdn.com_S003592...68fcd1c5b92c814cda17eaf7d131a.pdf Restricted Access | 88,07 kB | Adobe PDF | View/Open Request a copy |
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.