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https://repositorio.ufba.br/handle/ri/22703
metadata.dc.type: | Artigo de Periódico |
Title: | Cytogenetic studies: Premature chromosome condensation (PCC) in peripheral blood lymphocytes cultures and skin warts lesions cultures induced by Papillomavirus spontaneous infection in bovines |
Other Titles: | Revista de Ciências Médicas e Biológicas |
Authors: | Marins, Rachel Siqueira de Queiroz Simões Nogueira, Denise Monnerat Pereira, Sílvia Regina Ferreira Gonçalves Cassiano, Keila Mara Maues, Tábata Dias, Viviane Guimarães Moreira, Lio Carvalho, Eulógio Carlos Queiroz de |
metadata.dc.creator: | Marins, Rachel Siqueira de Queiroz Simões Nogueira, Denise Monnerat Pereira, Sílvia Regina Ferreira Gonçalves Cassiano, Keila Mara Maues, Tábata Dias, Viviane Guimarães Moreira, Lio Carvalho, Eulógio Carlos Queiroz de |
Abstract: | Abstract Papillomavirus is a dermotropic oncogenic DNA virus which induces benign and malignant lesions described in a wide variety of hosts. Evidences suggest that the virus is species and tissue specific. However several reports have shown the development of lesions in phylogenetically close hosts. We analyzed a total of 30 blood and tumors samples from bovines affected cutaneous papillomatosis lesions. Our study reported premature chromosome condensation (PCC) in peripheral blood lymphocytes cultures and in skin warts cells cultures, and we detected epithelial cellular hyperproliferation confirmed by histological tissues processing. The morphology of the PCC reflects the cell cycle phase-specific exhibiting levels of the prematurely condensed chromatin. These results indicated a failed in the cellular control mechanism with disruption of mitotic checkpoints induced by virus spontaneous infection. |
Keywords: | Papilomavírus – PCC Infecção em Bovinos. |
Publisher: | Instituto de Ciências da Saúde/ Universidade Federal da Bahia |
Citation: | R. Ci. méd. biol., v.9, Supl.1, p.3-9, 2010. |
metadata.dc.rights: | Acesso Aberto |
URI: | http://repositorio.ufba.br/ri/handle/ri/22703 |
Issue Date: | 2010 |
Appears in Collections: | Artigo Publicado em Periódico (PPGPIOS) |
Files in This Item:
File | Description | Size | Format | |
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1_v.9_1.pdf | 555,3 kB | Adobe PDF | View/Open |
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