Skip navigation
Universidade Federal da Bahia |
Repositório Institucional da UFBA
Use este identificador para citar ou linkar para este item: https://repositorio.ufba.br/handle/ri/17777
Tipo: Artigo de Periódico
Título: Inflammation in disseminated lesions: an analysis of CD4+, CD20+, CD68+, CD31+ and vW+ cells in non-ulcerated lesions of disseminated leishmaniasis
Título(s) alternativo(s): Memórias do Instituto Oswaldo Cruz
Autor(es): Mendes, Dayana Santos
Dantas, Marina Loyola
Gomes, Juliana Menezes
Santos, Washington Luis Conrado dos
Silva, Adriano Queiroz
Guimarães, Luiz Henrique
Machado, Paulo Roberto Lima
Carvalho Filho, Edgar Marcelino de
Arruda, Sérgio Marcos
Autor(es): Mendes, Dayana Santos
Dantas, Marina Loyola
Gomes, Juliana Menezes
Santos, Washington Luis Conrado dos
Silva, Adriano Queiroz
Guimarães, Luiz Henrique
Machado, Paulo Roberto Lima
Carvalho Filho, Edgar Marcelino de
Arruda, Sérgio Marcos
Abstract: Disseminated leishmaniasis (DL) differs from other clinical forms of the disease due to the presence of many non-ulcerated lesions (papules and nodules) in non-contiguous areas of the body. We describe the histopathology of DL non-ulcerated lesions and the presence of CD4-, CD20-, CD68-, CD31- and von Willebrand factor (vW)-positive cells in the inflamed area. We analysed eighteen biopsies from non-ulcerated lesions and quantified the inflamed areas and the expression of CD4, CD20, CD68, CD31 and vW using Image-Pro software (Media Cybernetics). Diffuse lymphoplasmacytic perivascular infiltrates were found in dermal skin. Inflammation was observed in 3-73% of the total biopsy area and showed a significant linear correlation with the number of vW+ vessels. The most common cells were CD68+ macrophages, CD20+ B-cells and CD4+ T-cells. A significant linear correlation between CD4+ and CD20+ cells and the size of the inflamed area was also found. Our findings show chronic inflammation in all DL non-ulcerated lesions predominantly formed by macrophages, plasmacytes and T and B-cells. As the inflamed area expanded, the number of granulomas and extent of the vascular framework increased. Thus, we demonstrate that vessels may have an important role in the clinical evolution of DL lesions.
Palavras-chave: Disseminated leishmaniasis
Histopathology
Immunohistochemistry
Tipo de Acesso: Acesso Aberto
URI: http://repositorio.ufba.br/ri/handle/ri/17777
Data do documento: 2013
Aparece nas coleções:Artigo Publicado em Periódico (Faculdade de Medicina)

Arquivos associados a este item:
Arquivo Descrição TamanhoFormato 
Dayana Santos Mendes.pdf957,96 kBAdobe PDFVisualizar/Abrir
Mostrar registro completo do item Visualizar estatísticas


Os itens no repositório estão protegidos por copyright, com todos os direitos reservados, salvo quando é indicado o contrário.