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Use este identificador para citar ou linkar para este item: https://repositorio.ufba.br/handle/ri/17777
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dc.contributor.authorMendes, Dayana Santos-
dc.contributor.authorDantas, Marina Loyola-
dc.contributor.authorGomes, Juliana Menezes-
dc.contributor.authorSantos, Washington Luis Conrado dos-
dc.contributor.authorSilva, Adriano Queiroz-
dc.contributor.authorGuimarães, Luiz Henrique-
dc.contributor.authorMachado, Paulo Roberto Lima-
dc.contributor.authorCarvalho Filho, Edgar Marcelino de-
dc.contributor.authorArruda, Sérgio Marcos-
dc.creatorMendes, Dayana Santos-
dc.creatorDantas, Marina Loyola-
dc.creatorGomes, Juliana Menezes-
dc.creatorSantos, Washington Luis Conrado dos-
dc.creatorSilva, Adriano Queiroz-
dc.creatorGuimarães, Luiz Henrique-
dc.creatorMachado, Paulo Roberto Lima-
dc.creatorCarvalho Filho, Edgar Marcelino de-
dc.creatorArruda, Sérgio Marcos-
dc.date.accessioned2015-05-28T14:28:14Z-
dc.date.available2015-05-28T14:28:14Z-
dc.date.issued2013-
dc.identifier.issn0074-0276-
dc.identifier.urihttp://repositorio.ufba.br/ri/handle/ri/17777-
dc.descriptionp. 18-22pt_BR
dc.description.abstractDisseminated leishmaniasis (DL) differs from other clinical forms of the disease due to the presence of many non-ulcerated lesions (papules and nodules) in non-contiguous areas of the body. We describe the histopathology of DL non-ulcerated lesions and the presence of CD4-, CD20-, CD68-, CD31- and von Willebrand factor (vW)-positive cells in the inflamed area. We analysed eighteen biopsies from non-ulcerated lesions and quantified the inflamed areas and the expression of CD4, CD20, CD68, CD31 and vW using Image-Pro software (Media Cybernetics). Diffuse lymphoplasmacytic perivascular infiltrates were found in dermal skin. Inflammation was observed in 3-73% of the total biopsy area and showed a significant linear correlation with the number of vW+ vessels. The most common cells were CD68+ macrophages, CD20+ B-cells and CD4+ T-cells. A significant linear correlation between CD4+ and CD20+ cells and the size of the inflamed area was also found. Our findings show chronic inflammation in all DL non-ulcerated lesions predominantly formed by macrophages, plasmacytes and T and B-cells. As the inflamed area expanded, the number of granulomas and extent of the vascular framework increased. Thus, we demonstrate that vessels may have an important role in the clinical evolution of DL lesions.pt_BR
dc.language.isoenpt_BR
dc.rightsAcesso Abertopt_BR
dc.sourcehttp://dx.doi.org/10.1590/S0074-02762013000100003pt_BR
dc.subjectDisseminated leishmaniasispt_BR
dc.subjectHistopathologypt_BR
dc.subjectImmunohistochemistrypt_BR
dc.titleInflammation in disseminated lesions: an analysis of CD4+, CD20+, CD68+, CD31+ and vW+ cells in non-ulcerated lesions of disseminated leishmaniasispt_BR
dc.title.alternativeMemórias do Instituto Oswaldo Cruzpt_BR
dc.typeArtigo de Periódicopt_BR
dc.identifier.numberv. 108, n. 1pt_BR
Aparece nas coleções:Artigo Publicado em Periódico (Faculdade de Medicina)

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