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metadata.dc.type: | Artigo de Periódico |
Title: | Estimation of Biodiesel Cytotoxicity by Using Acid Phosphatase as a Biomarker of Lysosomal Integrity |
Other Titles: | Bulletin of Environmental Contamination and Toxicology |
Authors: | Cruz, Andréa Cristina Santos da Leite, Maria Bernadete Neiva Lemos Rodrigues, Luiz Erlon Araújo Nascimento, Iracema Andrade |
metadata.dc.creator: | Cruz, Andréa Cristina Santos da Leite, Maria Bernadete Neiva Lemos Rodrigues, Luiz Erlon Araújo Nascimento, Iracema Andrade |
Abstract: | Biodiesel is promoted as environmentally less harmful than diesel fuel. Nevertheless its water-soluble-fraction (WSF) may contain methanol, which appears by a reversion of the transesterification reaction, when biodiesel contacts water. This paper evaluated the loss of the lysosomal membrane integrity in liver homogenate of juvenils Tilapia exposed to biodiesels-WSF, through the increase of the acid phosphatase activity, as an evidence of citotoxicity. Differences in the enzyme activity levels (3.4, 2.3 and 0.8 mU mg−1 total protein over the control value, which was 1.6 mU mg−1 total protein), found for castor oil, waste cooking-oil and palm oil-biodiesels, respectively, were indicative of their toxicity according to this decreasing trend. WSF-chromatograms suggest the cytotoxicity as related to methanol. |
Keywords: | Biodiesel Hepatotoxicity Lysosomal biomarker Acid phosphatase |
metadata.dc.rights: | Acesso Aberto |
URI: | http://repositorio.ufba.br/ri/handle/ri/17078 |
Issue Date: | 2012 |
Appears in Collections: | Artigo Publicado em Periódico (LABIOMAR) |
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