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metadata.dc.type: | Artigo de Periódico |
Title: | IL-17 Mediates Immunopathology in the Absence of IL-10 Following Leishmania major Infection |
Other Titles: | PLoS ONE |
Authors: | Lombana, Claudia Gonzalez Gimblet, Ciara Bacellar, Maria Olívia Amado Ramos Oliveira, Walker W. Passos, Sara Carvalho, Lucas Pedreira de Goldschmidt, Michael Carvalho Filho, Edgar Marcelino de Scott, Phillip |
metadata.dc.creator: | Lombana, Claudia Gonzalez Gimblet, Ciara Bacellar, Maria Olívia Amado Ramos Oliveira, Walker W. Passos, Sara Carvalho, Lucas Pedreira de Goldschmidt, Michael Carvalho Filho, Edgar Marcelino de Scott, Phillip |
Abstract: | Leishmaniasis, resulting from infection with the protozoan parasite Leishmania, consists of a wide spectrum of clinical manifestations, from healing cutaneous lesions to fatal visceral infections. A particularly severe form of cutaneous leishmaniasis, termed mucosal leishmaniasis, exhibits decreased IL-10 levels and an exaggerated inflammatory response that perpetuates the disease. Using a mouse model of leishmaniasis, we investigated what cytokines contribute to increased pathology when IL-10-mediated regulation is absent. Leishmania major infected C57BL/6 mice lacking IL-10 regulation developed larger lesions than controls, but fewer parasites. Both IFN-γ and IL-17 levels were substantially elevated in mice lacking the capacity to respond to IL-10. IFN-γ promoted an increased infiltration of monocytes, while IL-17 contributed to an increase in neutrophils. Surprisingly, however, we found that IFN-γ did not contribute to increased pathology, but instead regulated the IL-17 response. Thus, blocking IFN-γ led to a significant increase in IL-17, neutrophils and disease. Similarly, the production of IL-17 by cells from leishmaniasis patients was also regulated by IL-10 and IFN-γ. Additional studies found that the IL-1 receptor was required for both the IL-17 response and increased pathology. Therefore, we propose that regulating IL-17, possibly by downregulating IL-1β, may be a useful approach for controlling immunopathology in leishmaniasis. |
Keywords: | Leishmaniasis Interleukin-17 Interleukin-10 Leishmaniasis cutaneous |
metadata.dc.publisher.country: | Brasil |
metadata.dc.rights: | Acesso Aberto |
URI: | http://repositorio.ufba.br/ri/handle/ri/16684 |
Issue Date: | 2013 |
Appears in Collections: | Artigo Publicado em Periódico (Faculdade de Medicina) |
Files in This Item:
File | Description | Size | Format | |
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Claudia Gonzalez Lombana.pdf | 1,86 MB | Adobe PDF | View/Open |
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