Campo DC | Valor | Idioma |
dc.contributor.author | Lombana, Claudia Gonzalez | - |
dc.contributor.author | Gimblet, Ciara | - |
dc.contributor.author | Bacellar, Maria Olívia Amado Ramos | - |
dc.contributor.author | Oliveira, Walker W. | - |
dc.contributor.author | Passos, Sara | - |
dc.contributor.author | Carvalho, Lucas Pedreira de | - |
dc.contributor.author | Goldschmidt, Michael | - |
dc.contributor.author | Carvalho Filho, Edgar Marcelino de | - |
dc.contributor.author | Scott, Phillip | - |
dc.creator | Lombana, Claudia Gonzalez | - |
dc.creator | Gimblet, Ciara | - |
dc.creator | Bacellar, Maria Olívia Amado Ramos | - |
dc.creator | Oliveira, Walker W. | - |
dc.creator | Passos, Sara | - |
dc.creator | Carvalho, Lucas Pedreira de | - |
dc.creator | Goldschmidt, Michael | - |
dc.creator | Carvalho Filho, Edgar Marcelino de | - |
dc.creator | Scott, Phillip | - |
dc.date.accessioned | 2014-12-01T11:51:48Z | - |
dc.date.available | 2014-12-01T11:51:48Z | - |
dc.date.issued | 2013 | - |
dc.identifier.issn | 1932-6203 | - |
dc.identifier.uri | http://repositorio.ufba.br/ri/handle/ri/16684 | - |
dc.description | p. 1-14 | pt_BR |
dc.description.abstract | Leishmaniasis, resulting from infection with the protozoan parasite Leishmania, consists of a wide spectrum of clinical manifestations, from healing cutaneous lesions to fatal visceral infections. A particularly severe form of cutaneous leishmaniasis, termed mucosal leishmaniasis, exhibits decreased IL-10 levels and an exaggerated inflammatory response that perpetuates the disease. Using a mouse model of leishmaniasis, we investigated what cytokines contribute to increased pathology when IL-10-mediated regulation is absent. Leishmania major infected C57BL/6 mice lacking IL-10 regulation developed larger lesions than controls, but fewer parasites. Both IFN-γ and IL-17 levels were substantially elevated in mice lacking the capacity to respond to IL-10. IFN-γ promoted an increased infiltration of monocytes, while IL-17 contributed to an increase in neutrophils. Surprisingly, however, we found that IFN-γ did not contribute to increased pathology, but instead regulated the IL-17 response. Thus, blocking IFN-γ led to a significant increase in IL-17, neutrophils and disease. Similarly, the production of IL-17 by cells from leishmaniasis patients was also regulated by IL-10 and IFN-γ. Additional studies found that the IL-1 receptor was required for both the IL-17 response and increased pathology. Therefore, we propose that regulating IL-17, possibly by downregulating IL-1β, may be a useful approach for controlling immunopathology in leishmaniasis. | pt_BR |
dc.language.iso | en | pt_BR |
dc.rights | Acesso Aberto | pt_BR |
dc.source | http://dx.doi.org/10.1371/journal.ppat.1003243 | pt_BR |
dc.subject | Leishmaniasis | pt_BR |
dc.subject | Interleukin-17 | pt_BR |
dc.subject | Interleukin-10 | pt_BR |
dc.subject | Leishmaniasis cutaneous | pt_BR |
dc.title | IL-17 Mediates Immunopathology in the Absence of IL-10 Following Leishmania major Infection | pt_BR |
dc.title.alternative | PLoS ONE | pt_BR |
dc.type | Artigo de Periódico | pt_BR |
dc.identifier.number | v. 9, n. 3 | pt_BR |
dc.publisher.country | Brasil | pt_BR |
Aparece nas coleções: | Artigo Publicado em Periódico (Faculdade de Medicina)
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