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metadata.dc.type: | Artigo de Periódico |
Title: | Anti-inflammatory properties of rose oxide |
Other Titles: | International Immunopharmacology |
Authors: | Villarreal, Cristiane Flora Melo, Flavielle Martins de Nonato, Fabiana Regina Santana, Daniele Gomes Santos, Gisele Graça Leite dos Brustolim, Daniele Camargo, Enilton Aparecido Sousa, Damião P. de |
metadata.dc.creator: | Villarreal, Cristiane Flora Melo, Flavielle Martins de Nonato, Fabiana Regina Santana, Daniele Gomes Santos, Gisele Graça Leite dos Brustolim, Daniele Camargo, Enilton Aparecido Sousa, Damião P. de |
Abstract: | Rose-oxide is a fragrance found in roses and rose oil. There are no reports about the pharmacological activity of this molecule. The present study was undertaken to evaluate whether rose-oxide (RO) has anti-inflammatory properties and to investigate possible mechanisms involved with its effects. The anti-inflammatory activity of RO was first suggested by the formalin test in mice, an inflammatory pain model, because intraperitoneal (i.p.) administration of RO (50 and 100 mg/kg) inhibited only the late phase of this test. To further investigate the anti-inflammatory properties of RO, the complete Freund's adjuvant (CFA)- and carrageenan-induced paw inflammation models were used. Pre-treatment with RO (50 and 100 mg/kg) significantly reduced paw edema at 4, 6 and 24 h after the CFA injection. In addition, RO (100 mg/kg) reduced the IL-1β, but not TNF-α, local production induced by CFA. Administration of RO (25–100 mg/kg) decreased the paw edema induced by carrageenan in rats, which was more evident at 3 and 4 h after induction. In addition, neutrophil migration to the hind paw was measured by MPO assay after the carrageenan injection. The MPO activity was significantly inhibited by RO at 25–100 mg/kg, 4 h after stimulus. In another experimental set, administration of RO (25–100 mg/kg) significantly reduced the leukocyte migration in the carrageenan-induced peritonitis model in mice. The results described here are the first report of pharmacological properties of RO and strongly suggest that RO possesses anti-inflammatory activity related to its ability to inhibit the IL-1β production and the leukocyte migration. |
Keywords: | Essential oils Monoterpenes Anti-inflammatory Cytokines |
metadata.dc.rights: | Acesso Aberto |
URI: | http://repositorio.ufba.br/ri/handle/ri/16065 |
Issue Date: | 2012 |
Appears in Collections: | Artigo Publicado em Periódico (FAR) |
Files in This Item:
File | Description | Size | Format | |
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Cristiane Flora Villarreal.pdf | 502,86 kB | Adobe PDF | View/Open |
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