Campo DC | Valor | Idioma |
dc.contributor.author | Villarreal, Cristiane Flora | - |
dc.contributor.author | Melo, Flavielle Martins de | - |
dc.contributor.author | Nonato, Fabiana Regina | - |
dc.contributor.author | Santana, Daniele Gomes | - |
dc.contributor.author | Santos, Gisele Graça Leite dos | - |
dc.contributor.author | Brustolim, Daniele | - |
dc.contributor.author | Camargo, Enilton Aparecido | - |
dc.contributor.author | Sousa, Damião P. de | - |
dc.creator | Villarreal, Cristiane Flora | - |
dc.creator | Melo, Flavielle Martins de | - |
dc.creator | Nonato, Fabiana Regina | - |
dc.creator | Santana, Daniele Gomes | - |
dc.creator | Santos, Gisele Graça Leite dos | - |
dc.creator | Brustolim, Daniele | - |
dc.creator | Camargo, Enilton Aparecido | - |
dc.creator | Sousa, Damião P. de | - |
dc.date.accessioned | 2014-09-11T18:13:35Z | - |
dc.date.issued | 2012 | - |
dc.identifier.issn | 1567-5769 | - |
dc.identifier.uri | http://repositorio.ufba.br/ri/handle/ri/16065 | - |
dc.description | Texto completo: acesso restrito. p. 779–784 | pt_BR |
dc.description.abstract | Rose-oxide is a fragrance found in roses and rose oil. There are no reports about the pharmacological activity of this molecule. The present study was undertaken to evaluate whether rose-oxide (RO) has anti-inflammatory properties and to investigate possible mechanisms involved with its effects. The anti-inflammatory activity of RO was first suggested by the formalin test in mice, an inflammatory pain model, because intraperitoneal (i.p.) administration of RO (50 and 100 mg/kg) inhibited only the late phase of this test. To further investigate the anti-inflammatory properties of RO, the complete Freund's adjuvant (CFA)- and carrageenan-induced paw inflammation models were used. Pre-treatment with RO (50 and 100 mg/kg) significantly reduced paw edema at 4, 6 and 24 h after the CFA injection. In addition, RO (100 mg/kg) reduced the IL-1β, but not TNF-α, local production induced by CFA. Administration of RO (25–100 mg/kg) decreased the paw edema induced by carrageenan in rats, which was more evident at 3 and 4 h after induction. In addition, neutrophil migration to the hind paw was measured by MPO assay after the carrageenan injection. The MPO activity was significantly inhibited by RO at 25–100 mg/kg, 4 h after stimulus. In another experimental set, administration of RO (25–100 mg/kg) significantly reduced the leukocyte migration in the carrageenan-induced peritonitis model in mice. The results described here are the first report of pharmacological properties of RO and strongly suggest that RO possesses anti-inflammatory activity related to its ability to inhibit the IL-1β production and the leukocyte migration. | pt_BR |
dc.language.iso | en | pt_BR |
dc.rights | Acesso Aberto | pt_BR |
dc.source | http://dx.doi.org.ez10.periodicos.capes.gov.br/10.1016/j.intimp.2012.10.015 | pt_BR |
dc.subject | Essential oils | pt_BR |
dc.subject | Monoterpenes | pt_BR |
dc.subject | Anti-inflammatory | pt_BR |
dc.subject | Cytokines | pt_BR |
dc.title | Anti-inflammatory properties of rose oxide | pt_BR |
dc.title.alternative | International Immunopharmacology | pt_BR |
dc.type | Artigo de Periódico | pt_BR |
dc.identifier.number | v. 14, n. 4 | pt_BR |
dc.embargo.liftdate | 10000-01-01 | - |
Aparece nas coleções: | Artigo Publicado em Periódico (FAR)
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