Please use this identifier to cite or link to this item:
https://repositorio.ufba.br/handle/ri/15557
metadata.dc.type: | Artigo de Periódico |
Title: | Inflammation biomarkers in chronic hepatitis C: association with liver histopathology, HCV genotype and cryoglobulinemia |
Other Titles: | Inflammation Research |
Authors: | Paraná, Raymundo Atta, Maria Luiza Brito de Sousa Cabral, Milena Barreto de Arruda Santos, Gilvan Atta, Ajax Mercês |
metadata.dc.creator: | Paraná, Raymundo Atta, Maria Luiza Brito de Sousa Cabral, Milena Barreto de Arruda Santos, Gilvan Atta, Ajax Mercês |
Abstract: | Objective: This work investigated the profile of inflammation biomarkers in patients with chronic hepatitis C and its association with liver fibrosis, hepatic necroinflammatory activity, viral genotypes and cryoglobulinemia. Subjects and methods: Seventy-eight untreated patients were studied. Biomarker levels were determined by immunoassays, cryoglobulinemia by cryoprecipitation and liver histopathology investigated using METAVIR scores. Results: Decreased levels of α1-acid glycoprotein (AGP), C3 and haptoglobin (Hp) were observed in the patients (P < 0.0001). Increased α1-antitrypsin (P < 0.01) and ferritin (P < 0.0001) levels were found in this group, but C-reactive protein (CRP) and C4 levels were unaltered. Alanine aminotransferase inversely correlated with Hp (P < 0.01) and AGP (P = 0.01), whereas it was directly correlated with ferritin (P < 0.05) and AGP (P < 0.0001). The levels of CRP, C3 and C4 were lower in the patients with hepatic necroinflammatory activity (P < 0.05). Patients with advanced fibrosis had low levels of Hp and AGP (P < 0.05 and P < 0.01, respectively). Neither infection with different viral genotypes nor cryoglobulinemia caused an alteration in biomarker levels. Conclusion: Chronic hepatitis C virus infection alters the levels of some biomarkers, which are mainly observed in patients with liver fibrosis and hepatic necroinflammatory activity. |
Keywords: | Hepatitis C Inflammation biomarkers Liver histopathology Viral genotype Cryoglobulinemia |
metadata.dc.rights: | Acesso Aberto |
URI: | http://repositorio.ufba.br/ri/handle/ri/15557 |
Issue Date: | 2012 |
Appears in Collections: | Artigo Publicado em Periódico (Faculdade de Medicina) |
Files in This Item:
File | Description | Size | Format | |
---|---|---|---|---|
Raymundo Paraná.pdf | 270,16 kB | Adobe PDF | View/Open |
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.