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Campo DC | Valor | Idioma |
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dc.contributor.author | Paraná, Raymundo | - |
dc.contributor.author | Atta, Maria Luiza Brito de Sousa | - |
dc.contributor.author | Cabral, Milena Barreto de Arruda | - |
dc.contributor.author | Santos, Gilvan | - |
dc.contributor.author | Atta, Ajax Mercês | - |
dc.creator | Paraná, Raymundo | - |
dc.creator | Atta, Maria Luiza Brito de Sousa | - |
dc.creator | Cabral, Milena Barreto de Arruda | - |
dc.creator | Santos, Gilvan | - |
dc.creator | Atta, Ajax Mercês | - |
dc.date.accessioned | 2014-08-11T19:10:18Z | - |
dc.date.issued | 2012 | - |
dc.identifier.issn | 1023-3830 | - |
dc.identifier.uri | http://repositorio.ufba.br/ri/handle/ri/15557 | - |
dc.description | Texto completo: acesso restrito. p. 1101-1106 | pt_BR |
dc.description.abstract | Objective: This work investigated the profile of inflammation biomarkers in patients with chronic hepatitis C and its association with liver fibrosis, hepatic necroinflammatory activity, viral genotypes and cryoglobulinemia. Subjects and methods: Seventy-eight untreated patients were studied. Biomarker levels were determined by immunoassays, cryoglobulinemia by cryoprecipitation and liver histopathology investigated using METAVIR scores. Results: Decreased levels of α1-acid glycoprotein (AGP), C3 and haptoglobin (Hp) were observed in the patients (P < 0.0001). Increased α1-antitrypsin (P < 0.01) and ferritin (P < 0.0001) levels were found in this group, but C-reactive protein (CRP) and C4 levels were unaltered. Alanine aminotransferase inversely correlated with Hp (P < 0.01) and AGP (P = 0.01), whereas it was directly correlated with ferritin (P < 0.05) and AGP (P < 0.0001). The levels of CRP, C3 and C4 were lower in the patients with hepatic necroinflammatory activity (P < 0.05). Patients with advanced fibrosis had low levels of Hp and AGP (P < 0.05 and P < 0.01, respectively). Neither infection with different viral genotypes nor cryoglobulinemia caused an alteration in biomarker levels. Conclusion: Chronic hepatitis C virus infection alters the levels of some biomarkers, which are mainly observed in patients with liver fibrosis and hepatic necroinflammatory activity. | pt_BR |
dc.language.iso | en | pt_BR |
dc.rights | Acesso Aberto | pt_BR |
dc.source | http://dx.doi.org/ 10.1007/s00011-012-0502-2 | pt_BR |
dc.subject | Hepatitis C | pt_BR |
dc.subject | Inflammation biomarkers | pt_BR |
dc.subject | Liver histopathology | pt_BR |
dc.subject | Viral genotype | pt_BR |
dc.subject | Cryoglobulinemia | pt_BR |
dc.title | Inflammation biomarkers in chronic hepatitis C: association with liver histopathology, HCV genotype and cryoglobulinemia | pt_BR |
dc.title.alternative | Inflammation Research | pt_BR |
dc.type | Artigo de Periódico | pt_BR |
dc.identifier.number | v. 61, n. 10 | pt_BR |
dc.embargo.liftdate | 10000-01-01 | - |
Aparece nas coleções: | Artigo Publicado em Periódico (Faculdade de Medicina) |
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Arquivo | Descrição | Tamanho | Formato | |
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Raymundo Paraná.pdf | 270,16 kB | Adobe PDF | Visualizar/Abrir |
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