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https://repositorio.ufba.br/handle/ri/14891
metadata.dc.type: | Artigo de Periódico |
Título : | Involvement of potassium channels in vasorelaxant effect induced by valeriana prionophylla Standl. in rat mesenteric artery |
Otros títulos : | Evidence-Based Complementary and Alternative Medicine |
Autor : | Reis, Milena Ramos Oliveira Filho, Abrahão Alves de Rodrigues, Lilia Simone Urzedo Araújo, Jaíse Paiva Maciel, Priscilla Maria Pereira Albuquerque, Jamile Morais de Cehinel Filho, Valdir Cáceres, Armando Fregoneze, Josmara Bartolomei Medeiros, Isac Almeida de Silva, Darizy Flávia |
metadata.dc.creator: | Reis, Milena Ramos Oliveira Filho, Abrahão Alves de Rodrigues, Lilia Simone Urzedo Araújo, Jaíse Paiva Maciel, Priscilla Maria Pereira Albuquerque, Jamile Morais de Cehinel Filho, Valdir Cáceres, Armando Fregoneze, Josmara Bartolomei Medeiros, Isac Almeida de Silva, Darizy Flávia |
Resumen : | Assays in vitro and in vivo were performed on extract from roots and leaves from the Valeriana prionophylla Standl. (VPR and VPF, resp.). In phenylephrine (1 μM) precontracted rings, VPR (0.01–300 μg/mL) induced a concentration-dependent relaxation (maximum response (MR) = 75.4 ± 4.0%, EC50 = 5.97 (3.8–9.3) μg/mL, ]); this effect was significantly modified after removal of the endothelium (EC50 = 39.6 (27.2–57.6) μg/mL, ). However, VPF-induced vasorelaxation was less effective compared to VPR. When rings were preincubated with L-NAME (100 μM) or indomethacin (10 μM), the endothelium-dependent relaxation induced by VPR was significantly attenuated (MR = 20.9 ± 2.3%, 34.2 ± 2.9%, resp., ). In rings denuded endothelium, precontracted with KCl (80 mM), or in preparations pretreated with KCl (20 mM) or tetraethylammonium (1 or 3 mM), the vasorelaxant activity of VPR was significantly attenuated (MR = 40.0 ± 8.2, ; 50.5 ± 6.0%; 49.3 ± 6.4%; 46.8 ± 6.2%; resp., ). In contrast, neither glibenclamide (10 μM), barium chloride (30 μM), nor 4-aminopyridine (1 mM) affected VPR-induced relaxation. Taken together, these results demonstrate that hypotension induced by VPR seems to involve, at least in part, a vascular component. Furthermore, endothelium-independent relaxation induced by VPR involves K+ channels activation, most likely due to BKCa channels, in the rat superior mesenteric artery. |
metadata.dc.publisher.country: | Brasil |
metadata.dc.rights: | Acesso Aberto |
URI : | http://repositorio.ufba.br/ri/handle/ri/14891 |
Fecha de publicación : | 2013 |
Aparece en las colecciones: | Artigo Publicado em Periódico (ICS) |
Ficheros en este ítem:
Fichero | Descripción | Tamaño | Formato | |
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10.11552013-147670.pdf | 1,86 MB | Adobe PDF | Visualizar/Abrir |
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