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Use este identificador para citar ou linkar para este item: https://repositorio.ufba.br/handle/ri/14891
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dc.contributor.authorReis, Milena Ramos-
dc.contributor.authorOliveira Filho, Abrahão Alves de-
dc.contributor.authorRodrigues, Lilia Simone Urzedo-
dc.contributor.authorAraújo, Jaíse Paiva-
dc.contributor.authorMaciel, Priscilla Maria Pereira-
dc.contributor.authorAlbuquerque, Jamile Morais de-
dc.contributor.authorCehinel Filho, Valdir-
dc.contributor.authorCáceres, Armando-
dc.contributor.authorFregoneze, Josmara Bartolomei-
dc.contributor.authorMedeiros, Isac Almeida de-
dc.contributor.authorSilva, Darizy Flávia-
dc.creatorReis, Milena Ramos-
dc.creatorOliveira Filho, Abrahão Alves de-
dc.creatorRodrigues, Lilia Simone Urzedo-
dc.creatorAraújo, Jaíse Paiva-
dc.creatorMaciel, Priscilla Maria Pereira-
dc.creatorAlbuquerque, Jamile Morais de-
dc.creatorCehinel Filho, Valdir-
dc.creatorCáceres, Armando-
dc.creatorFregoneze, Josmara Bartolomei-
dc.creatorMedeiros, Isac Almeida de-
dc.creatorSilva, Darizy Flávia-
dc.date.accessioned2014-05-01T13:04:25Z-
dc.date.available2014-05-01T13:04:25Z-
dc.date.issued2013-
dc.identifier.issn1741-427X-
dc.identifier.urihttp://repositorio.ufba.br/ri/handle/ri/14891-
dc.descriptionp. 1-10pt_BR
dc.description.abstractAssays in vitro and in vivo were performed on extract from roots and leaves from the Valeriana prionophylla Standl. (VPR and VPF, resp.). In phenylephrine (1 μM) precontracted rings, VPR (0.01–300 μg/mL) induced a concentration-dependent relaxation (maximum response (MR) = 75.4 ± 4.0%, EC50 = 5.97 (3.8–9.3) μg/mL, ]); this effect was significantly modified after removal of the endothelium (EC50 = 39.6 (27.2–57.6) μg/mL, ). However, VPF-induced vasorelaxation was less effective compared to VPR. When rings were preincubated with L-NAME (100 μM) or indomethacin (10 μM), the endothelium-dependent relaxation induced by VPR was significantly attenuated (MR = 20.9 ± 2.3%, 34.2 ± 2.9%, resp., ). In rings denuded endothelium, precontracted with KCl (80 mM), or in preparations pretreated with KCl (20 mM) or tetraethylammonium (1 or 3 mM), the vasorelaxant activity of VPR was significantly attenuated (MR = 40.0 ± 8.2, ; 50.5 ± 6.0%; 49.3 ± 6.4%; 46.8 ± 6.2%; resp., ). In contrast, neither glibenclamide (10 μM), barium chloride (30 μM), nor 4-aminopyridine (1 mM) affected VPR-induced relaxation. Taken together, these results demonstrate that hypotension induced by VPR seems to involve, at least in part, a vascular component. Furthermore, endothelium-independent relaxation induced by VPR involves K+ channels activation, most likely due to BKCa channels, in the rat superior mesenteric artery.pt_BR
dc.language.isoenpt_BR
dc.rightsAcesso Abertopt_BR
dc.sourcehttp://dx.doi.org/10.1155/2013/147670pt_BR
dc.titleInvolvement of potassium channels in vasorelaxant effect induced by valeriana prionophylla Standl. in rat mesenteric arterypt_BR
dc.title.alternativeEvidence-Based Complementary and Alternative Medicinept_BR
dc.typeArtigo de Periódicopt_BR
dc.publisher.countryBrasilpt_BR
Aparece nas coleções:Artigo Publicado em Periódico (ICS)

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