Por favor, use este identificador para citar o enlazar este ítem:
https://repositorio.ufba.br/handle/ri/14352
metadata.dc.type: | Artigo de Periódico |
Título : | α-Thalassemia 2, 3.7 kb deletion and hemoglobin AC heterozygosity in pregnancy: a molecular and hematological analysis |
Otros títulos : | Clinical & Laboratory Haematology |
Autor : | Gonçalves, M. de Souza Couto, Fábio David Albuquerque, Arlete Barreto Lins de Adorno, Elisângela Vitória Moura Neto, José Pereira de Abbehusen, Luciana de Freitas Oliveira, J. L. B. de Reis, M. G. dos |
metadata.dc.creator: | Gonçalves, M. de Souza Couto, Fábio David Albuquerque, Arlete Barreto Lins de Adorno, Elisângela Vitória Moura Neto, José Pereira de Abbehusen, Luciana de Freitas Oliveira, J. L. B. de Reis, M. G. dos |
Resumen : | α-Thalassemia is a synthesis hemoglobinopathy with a worldwide distribution. α-thalassemia-23.7kb (α-Thal23.7kb) was investigated by PCR and standard hematologic analysis techniques in 106 pregnant women – 53 heterozygous for hemoglobin (Hb) A and C (AC) and 53 homozygous for the normal Hb A (AA) with similar ages and race ancestry. Eleven (21%) of AC women were α-Thal23.7kb heterozygous and 1 (2%) was homozygous, while 12 AA women (23%) were heterozygous. In the AA group, the MCV differed among those with normal α genes and those with α-Thal23.7kb (P = 0.031). Statistical analysis of AC group patients with normal α genes and α-Thal23.7kb carriers showed differences in MCV (P = 0.001); MCH (P = 0.003) and Hb C concentrations (P = 0.011). Analysis of AA and AC group patients with normal α genes showed differences in RBC (P = 0.033), Hb concentration (P = 0.003) and MCHC (P < 0.0001). There were no statistically significant differences for any hematologic parameters between AC and AA group patients with the α-Thal23.7kb genotype. The AC α-Thal23.7kb homozygous women had low hematologic parameters. Serum ferritin levels were normal among the groups studied. These results emphasize the importance of diagnosis and follow-up of patients with hemoglobinopathy carriers during pregnancy in order to administer adequate therapy and avoid further complications for mothers and newborns. |
Palabras clave : | Hemoglobinopathies Hemoglobin C Pregnancy Thalassemia Hematologic parameters |
metadata.dc.rights: | Acesso Aberto |
URI : | http://repositorio.ufba.br/ri/handle/ri/14352 |
Fecha de publicación : | 2003 |
Aparece en las colecciones: | Artigo Publicado em Periódico (Química) |
Ficheros en este ítem:
Fichero | Descripción | Tamaño | Formato | |
---|---|---|---|---|
M. De Souza Gonçalves.pdf | 176,52 kB | Adobe PDF | Visualizar/Abrir |
Los ítems de DSpace están protegidos por copyright, con todos los derechos reservados, a menos que se indique lo contrario.