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Use este identificador para citar ou linkar para este item: https://repositorio.ufba.br/handle/ri/14352
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dc.contributor.authorGonçalves, M. de Souza-
dc.contributor.authorCouto, Fábio David-
dc.contributor.authorAlbuquerque, Arlete Barreto Lins de-
dc.contributor.authorAdorno, Elisângela Vitória-
dc.contributor.authorMoura Neto, José Pereira de-
dc.contributor.authorAbbehusen, Luciana de Freitas-
dc.contributor.authorOliveira, J. L. B. de-
dc.contributor.authorReis, M. G. dos-
dc.creatorGonçalves, M. de Souza-
dc.creatorCouto, Fábio David-
dc.creatorAlbuquerque, Arlete Barreto Lins de-
dc.creatorAdorno, Elisângela Vitória-
dc.creatorMoura Neto, José Pereira de-
dc.creatorAbbehusen, Luciana de Freitas-
dc.creatorOliveira, J. L. B. de-
dc.creatorReis, M. G. dos-
dc.date.accessioned2014-01-14T14:54:10Z-
dc.date.issued2003-
dc.identifier.issn0141-9854-
dc.identifier.urihttp://repositorio.ufba.br/ri/handle/ri/14352-
dc.descriptionTexto completo: acesso restrito. p. 29–34pt_BR
dc.description.abstractα-Thalassemia is a synthesis hemoglobinopathy with a worldwide distribution. α-thalassemia-23.7kb (α-Thal23.7kb) was investigated by PCR and standard hematologic analysis techniques in 106 pregnant women – 53 heterozygous for hemoglobin (Hb) A and C (AC) and 53 homozygous for the normal Hb A (AA) with similar ages and race ancestry. Eleven (21%) of AC women were α-Thal23.7kb heterozygous and 1 (2%) was homozygous, while 12 AA women (23%) were heterozygous. In the AA group, the MCV differed among those with normal α genes and those with α-Thal23.7kb (P = 0.031). Statistical analysis of AC group patients with normal α genes and α-Thal23.7kb carriers showed differences in MCV (P = 0.001); MCH (P = 0.003) and Hb C concentrations (P = 0.011). Analysis of AA and AC group patients with normal α genes showed differences in RBC (P = 0.033), Hb concentration (P = 0.003) and MCHC (P < 0.0001). There were no statistically significant differences for any hematologic parameters between AC and AA group patients with the α-Thal23.7kb genotype. The AC α-Thal23.7kb homozygous women had low hematologic parameters. Serum ferritin levels were normal among the groups studied. These results emphasize the importance of diagnosis and follow-up of patients with hemoglobinopathy carriers during pregnancy in order to administer adequate therapy and avoid further complications for mothers and newborns.pt_BR
dc.language.isoenpt_BR
dc.rightsAcesso Abertopt_BR
dc.sourcehttp://dx.doi.org/ 10.1046/j.1365-2257.2003.00487.xpt_BR
dc.subjectHemoglobinopathiespt_BR
dc.subjectHemoglobin Cpt_BR
dc.subjectPregnancypt_BR
dc.subjectThalassemiapt_BR
dc.subjectHematologic parameterspt_BR
dc.titleα-Thalassemia 2, 3.7 kb deletion and hemoglobin AC heterozygosity in pregnancy: a molecular and hematological analysispt_BR
dc.title.alternativeClinical & Laboratory Haematologypt_BR
dc.typeArtigo de Periódicopt_BR
dc.identifier.numberv. 25, n. 1pt_BR
dc.embargo.liftdate10000-01-01-
Aparece nas coleções:Artigo Publicado em Periódico (Química)

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