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https://repositorio.ufba.br/handle/ri/12735
metadata.dc.type: | Artigo de Periódico |
Título : | Chronic intestinal helminth infections are associated with immune hyporesponsiveness and induction of a regulatory network |
Otros títulos : | Infection and Immunity |
Autor : | Figueiredo, Camila Alexandrina Barreto, Mauricio Lima Rodrigues, Laura C. Cooper, Philip J. Silva, Nívea Bispo Amorim, Leila Denise Alves Ferreira Alcântara-Neves, Neuza Maria |
metadata.dc.creator: | Figueiredo, Camila Alexandrina Barreto, Mauricio Lima Rodrigues, Laura C. Cooper, Philip J. Silva, Nívea Bispo Amorim, Leila Denise Alves Ferreira Alcântara-Neves, Neuza Maria |
Resumen : | Helminth infections have been associated with protection against allergy and autoimmune diseases. We investigated the effects of chronic infections with Ascaris lumbricoides and Trichuris trichiura (measured twice over a 5-year period) on cytokine and antibody responses. We collected blood from 1,060 children aged 4 to 11 years living in a poor urban area of Brazil and measured Th1 (gamma interferon [IFN-γ]) and Th2 (interleukin-5 [IL-5] and IL-13) cytokines and the regulatory cytokine IL-10 in unstimulated and stimulated (with mitogen or A. lumbricoides antigens) cultures of peripheral blood leukocytes and levels of total IgE and anti-A. lumbricoides IgG4 and IgE in serum. Intestinal helminth infections were associated with an increased proportion of children producing IL-5 in response to A. lumbricoides and producing IL-10 spontaneously, especially among coinfected and chronically infected children. Helminth infections were associated with a generalized suppression of cytokine responses to mitogen. Levels of total IgE and anti-A. lumbricoides IgG4 and IgE were especially elevated in chronically infected children. In conclusion, intestinal helminth infections were associated with a typical Th2 immune response profile and with the induction of immune hyporesponsiveness that was associated with greater frequencies of the production of spontaneous IL-10. |
URI : | http://www.repositorio.ufba.br/ri/handle/ri/12735 |
Fecha de publicación : | 2010 |
Aparece en las colecciones: | Artigo Publicado em Periódico Estrangeiro (ISC) |
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Fichero | Descripción | Tamaño | Formato | |
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Infect. Immun.-2010-Figueiredo-3160-7.pdf Restricted Access | 746,9 kB | Adobe PDF | Visualizar/Abrir Request a copy |
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