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Campo DC | Valor | Idioma |
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dc.contributor.author | Figueiredo, Camila Alexandrina | - |
dc.contributor.author | Barreto, Mauricio Lima | - |
dc.contributor.author | Rodrigues, Laura C. | - |
dc.contributor.author | Cooper, Philip J. | - |
dc.contributor.author | Silva, Nívea Bispo | - |
dc.contributor.author | Amorim, Leila Denise Alves Ferreira | - |
dc.contributor.author | Alcântara-Neves, Neuza Maria | - |
dc.creator | Figueiredo, Camila Alexandrina | - |
dc.creator | Barreto, Mauricio Lima | - |
dc.creator | Rodrigues, Laura C. | - |
dc.creator | Cooper, Philip J. | - |
dc.creator | Silva, Nívea Bispo | - |
dc.creator | Amorim, Leila Denise Alves Ferreira | - |
dc.creator | Alcântara-Neves, Neuza Maria | - |
dc.date.accessioned | 2013-08-26T15:11:27Z | - |
dc.date.issued | 2010 | - |
dc.identifier.issn | 0019-9567 | - |
dc.identifier.uri | http://www.repositorio.ufba.br/ri/handle/ri/12735 | - |
dc.description | Texto completo: acesso restrito. p.3160-3167 | pt_BR |
dc.description.abstract | Helminth infections have been associated with protection against allergy and autoimmune diseases. We investigated the effects of chronic infections with Ascaris lumbricoides and Trichuris trichiura (measured twice over a 5-year period) on cytokine and antibody responses. We collected blood from 1,060 children aged 4 to 11 years living in a poor urban area of Brazil and measured Th1 (gamma interferon [IFN-γ]) and Th2 (interleukin-5 [IL-5] and IL-13) cytokines and the regulatory cytokine IL-10 in unstimulated and stimulated (with mitogen or A. lumbricoides antigens) cultures of peripheral blood leukocytes and levels of total IgE and anti-A. lumbricoides IgG4 and IgE in serum. Intestinal helminth infections were associated with an increased proportion of children producing IL-5 in response to A. lumbricoides and producing IL-10 spontaneously, especially among coinfected and chronically infected children. Helminth infections were associated with a generalized suppression of cytokine responses to mitogen. Levels of total IgE and anti-A. lumbricoides IgG4 and IgE were especially elevated in chronically infected children. In conclusion, intestinal helminth infections were associated with a typical Th2 immune response profile and with the induction of immune hyporesponsiveness that was associated with greater frequencies of the production of spontaneous IL-10. | pt_BR |
dc.language.iso | en | pt_BR |
dc.source | http://dx.doi.org/10.1128/IAI.01228-09 | pt_BR |
dc.title | Chronic intestinal helminth infections are associated with immune hyporesponsiveness and induction of a regulatory network | pt_BR |
dc.title.alternative | Infection and Immunity | pt_BR |
dc.type | Artigo de Periódico | pt_BR |
dc.identifier.number | v. 78, n. 7 | pt_BR |
dc.embargo.liftdate | 10000-01-01 | - |
Aparece nas coleções: | Artigo Publicado em Periódico Estrangeiro (ISC) |
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Infect. Immun.-2010-Figueiredo-3160-7.pdf Restricted Access | 746,9 kB | Adobe PDF | Visualizar/Abrir Solicitar uma cópia |
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