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metadata.dc.type: | Artigo de Periódico |
Title: | Interleukin 6 and AIDS-Associated Kaposi's Sarcoma: A Nested Case Control Study within the Multicenter AIDS Cohort Study |
Other Titles: | AIDS Research and Human Retroviruses |
Authors: | Dourado, Maria Inês Costa Martínez-Maza, Otoniel Kishimoto, Tadamitsu Suzuki, Hiromasa Detels, Roger |
metadata.dc.creator: | Dourado, Maria Inês Costa Martínez-Maza, Otoniel Kishimoto, Tadamitsu Suzuki, Hiromasa Detels, Roger |
Abstract: | Since the beginning of the AIDS epidemic, there has been considerable research on the etiology of Kaposi's sarcoma (KS) among HlV-infected individuals. A number of studies have confirmed that HIV or HIV-encoded products can interact with human cells to induce the production of cytokines, including interleukin 6 (IL-6). In vitro observations have indicated that AIDS-KS cells can produce significant levels of IL-6 and also respond to this cytokine. Preliminary data suggested that IL-6 may be elevated among HlV-infected individuals that subsequently develop AIDS-KS. The objective of this study was to determine if elevated levels of IL- 6 are associated with an increased incidence of AIDS-KS compared to other AIDS-defining illnesses such as opportunistic infections (OIs). Serum IL-6 levels were determined by ELISA in frozen sera collected from participants in the Multicenter AIDS Cohort Study (MACS) at 6 months prior to AIDS diagnosis, in 73 cases (AIDS-KS), and 152 controls (OI). Elevated IL-6 levels were more prevalent among men with AIDS-OI than those with AIDS-KS: crude odds ratio (OR), 0.4 (95% CI, 0.2-0.9). Models of multivaríate logistic regression were used to study potential confounders. Sexual behavior variables did not seem to confound the association between IL-6 and AIDS-KS. The higher prevalence of IL-6 among controls could be explained by the association of higher levels of IL-6 with lower levels of CD4 T cell number. IL-6 may be a marker of severe immune dysfunction among HIV-infected individuals. |
Publisher: | AIDS Research and Human Retroviruses |
URI: | http://www.repositorio.ufba.br/ri/handle/ri/12730 |
Issue Date: | 1997 |
Appears in Collections: | Artigo Publicado em Periódico Estrangeiro (ISC) |
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