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Campo DC | Valor | Idioma |
---|---|---|
dc.contributor.author | Dourado, Maria Inês Costa | - |
dc.contributor.author | Martínez-Maza, Otoniel | - |
dc.contributor.author | Kishimoto, Tadamitsu | - |
dc.contributor.author | Suzuki, Hiromasa | - |
dc.contributor.author | Detels, Roger | - |
dc.creator | Dourado, Maria Inês Costa | - |
dc.creator | Martínez-Maza, Otoniel | - |
dc.creator | Kishimoto, Tadamitsu | - |
dc.creator | Suzuki, Hiromasa | - |
dc.creator | Detels, Roger | - |
dc.date.accessioned | 2013-08-26T13:28:14Z | - |
dc.date.available | 2013-08-26T13:28:14Z | - |
dc.date.issued | 1997 | - |
dc.identifier.issn | 0889-2229 | - |
dc.identifier.uri | http://www.repositorio.ufba.br/ri/handle/ri/12730 | - |
dc.description | p. 781-788 | pt_BR |
dc.description.abstract | Since the beginning of the AIDS epidemic, there has been considerable research on the etiology of Kaposi's sarcoma (KS) among HlV-infected individuals. A number of studies have confirmed that HIV or HIV-encoded products can interact with human cells to induce the production of cytokines, including interleukin 6 (IL-6). In vitro observations have indicated that AIDS-KS cells can produce significant levels of IL-6 and also respond to this cytokine. Preliminary data suggested that IL-6 may be elevated among HlV-infected individuals that subsequently develop AIDS-KS. The objective of this study was to determine if elevated levels of IL- 6 are associated with an increased incidence of AIDS-KS compared to other AIDS-defining illnesses such as opportunistic infections (OIs). Serum IL-6 levels were determined by ELISA in frozen sera collected from participants in the Multicenter AIDS Cohort Study (MACS) at 6 months prior to AIDS diagnosis, in 73 cases (AIDS-KS), and 152 controls (OI). Elevated IL-6 levels were more prevalent among men with AIDS-OI than those with AIDS-KS: crude odds ratio (OR), 0.4 (95% CI, 0.2-0.9). Models of multivaríate logistic regression were used to study potential confounders. Sexual behavior variables did not seem to confound the association between IL-6 and AIDS-KS. The higher prevalence of IL-6 among controls could be explained by the association of higher levels of IL-6 with lower levels of CD4 T cell number. IL-6 may be a marker of severe immune dysfunction among HIV-infected individuals. | pt_BR |
dc.language.iso | en | pt_BR |
dc.publisher | AIDS Research and Human Retroviruses | pt_BR |
dc.source | http://online.liebertpub.com.ez10.periodicos.capes.gov.br/doi/pdf/10.1089/aid.1997.13.781 | pt_BR |
dc.title | Interleukin 6 and AIDS-Associated Kaposi's Sarcoma: A Nested Case Control Study within the Multicenter AIDS Cohort Study | pt_BR |
dc.title.alternative | AIDS Research and Human Retroviruses | pt_BR |
dc.type | Artigo de Periódico | pt_BR |
dc.description.localpub | Salvador | pt_BR |
dc.identifier.number | v. 13, n. 9 | pt_BR |
Aparece nas coleções: | Artigo Publicado em Periódico Estrangeiro (ISC) |
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