• A situação da atenção farmacêutica: revolução ou penumbra paradigmática? 

  Penaforte, Thais; Castro, Sabrina (2021-11)

  Com o propósito de compreender a situação da atenção farmacêutica em um sistema municipal de saúde, tomou-se como ponto de partida o estudo do grau de adesão e incorporação do paradigma profis- sional que orienta essa ...
• O negacionismo enquanto política: o debate da cloroquina em uma comissão parlamentar 

  Penaforte, Thais (2021-07)

  O objetivo deste trabalho foi esclarecer os movimentos e desdobramentos sobre a política terapêutica da cloroquina, no Parlamento brasileiro, a fim de identificar os fatores que a situaram no contexto da ação pública contra ...
• Bi-Functional Biobased Packing of the Cassava Starch, Glycerol, Licuri Nanocellulose and Red Propolis 

  Costa, Samantha Serra; Druzian, Janice Izabel; Machado, Bruna Aparecida Souza; Souza, Carolina Oliveira de; Guimarães, Alaíse Gil (Brasil, 2014)

  The aim of this study was to characterize and determine the bi-functional efficacy of active packaging films produced with starch (4%) and glycerol (1.0%), reinforced with cellulose nanocrystals (0–1%) and activated with ...
• Antinociceptive Properties of Physalins from Physalis angulata 

  Lima, Milena da Silva; Evangelista, Afrânio Ferreira; Santos, Gisele Graça Leite dos; Ribeiro, Ivone Maria; Tomassini, Therezinha Coelho Barbosa; Soares, Milena Botelho Pereira; Villarreal, Cristiane Flora (2014)

  Pain is the most common reason a patient sees a physician. Nevertheless, the use of typical painkillers is not completely effective in controlling all pain syndromes; therefore further attempts have been made to develop ...
• Elevated manganese exposure and school-aged children's behavior: A gender-stratified analysis 

  Menezes Filho, José Antônio; Vivas, Chrissie F. de Carvalho; Viana, Gustavo Freitas de Sousa; Ferreira, Junia R. Dutra; Nunes, Lorena S.; Mergler, Donna; Abreu, José Neander Silva (2014)

  High levels of waterborne manganese have been associated with problematic behavior in school-aged children, however to date this has not been reported for children exposed to airborne manganese. The objective of the present ...
• Noninvasive biomarkers of manganese exposure and neuropsychological effects in environmentally exposed adults in Brazil 

  Viana, Gustavo Freitas de Sousa; Carvalho, Chrissie Ferreira de; Nunes, Lorena S.; Rodrigues, Juliana L. G.; Ribeiro, Nathália S.; Almeida, Diego A. de; Ferreira, Junia R. Dutra; Abreu, José Neander Silva; Menezes Filho, José Antônio (2014)

  Manganese (Mn), an essential element to humans, in excess can cause neurotoxic damage. So far, Mn exposure assessment has no ideal biomarker. This study aims to investigate the association between Mn exposure, using ...
• A fully validated microbiological assay to evaluate the potency of ceftriaxone sodium 

  Manfio, Maria Luisa; Agarrayua, Danielle Araújo; Machado, Jaison Carlosso; Schmidt, Cleber Alberto (2013)

  Ceftriaxone (CFTX) sodium is a third-generation, broad-spectrum cephalosporin that is resistant to beta-lactamases. An alternative bioassay for the assessment of the potency of this drug in pharmaceutical formulations has ...
• Incorporação de urucum como aditivo antioxidante em embalagens biodegradáveis a base de quitosana 

  Santana, Maria Cecília Castelo Branco de; Machado, Bruna Aparecida Souza; Silva, Tamara do Nascimento da; Nunes, Itaciara Larroza; Druzian, Janice Izabel (Brasil, 2013)

  O objetivo do trabalho foi desenvolver e caracterizar uma embalagem biodegradável, utilizando como matriz polimérica a quitosana, plastificada com glicerol, bem como avaliar o efeito da adição de um aditivo antioxidante ...
• Phenolic compounds, methylxanthines and antioxidant activity in cocoa mass and chocolates produced from "witch broom disease" resistant and non resistant cocoa cultivars 

  Leite, Paula Bacelar; Maciel, Leonardo Fonseca; Opretzka, Luiza Carolina França; Soares, Sérgio Eduardo; Bispo, Eliete da Silva (Brasil, 2013)

  The "witch broom disease" caused by the fungus called Moniliophthora perniciosa is one of the most important cocoa diseases in Latin America, causing around 70% production reduction in the southern Bahia. In attempt to ...
• Evidence for the Involvement of Descending Pain-Inhibitory Mechanisms in the Antinociceptive Effect of Hecogenin Acetate 

  Gama, Kelly Barbosa; Quintans, Jullyana de Souza Siqueira; Antoniolli, Ângelo Roberto; Quintans Júnior, Lucindo José; Santana, Wagno Alcântara de; Branco, Alexsandro; Soares, Milena Botelho Pereira; Villarreal, Cristiane Flora (2013)

  Hecogenin is a sapogenin present in the leaves of species from the Agave genus, with a wide spectrum of reported pharmacological activities. The present study was undertaken to evaluate whether hecogenin acetate (1) has ...
• Molecular Dynamics Simulations of Peptide Inhibitors Complexed With Trypanosoma cruzi Trypanothione Reductase 

  Batista, Paulo Ricardo; Pita, Samuel Silva Da Rocha; Albuquerque, Magaly Girão; Pascutti, Pedro Geraldo (2012)

  The drugs against tropical neglected diseases, especially Chagas’ Disease, were launched more than 30 years ago, and the development of resistance requires the discovery of new and more effective chemotherapeutic agents. ...
• Bioactive Oleanane, Lupane and Ursane Triterpene Acid Derivatives 

  Silva, Maria de L. e; David, Juceni Pereira de Lima; Silva, Lidércia C. R. C.; Santos, Rauldenis Almeida Fonseca; David, Jorge Mauricio; Lima, Luciano S.; Reis, Pedro S.; Fontana, Renato (Brasil, 2012)

  Betulinic, ursolic and oleanolic acids isolated from the aerial parts of Eriope blanchetii (Lamiaceae) were subjected to different esterification reactions, yielding 12 C-3 position ester derivatives. All compounds were ...
• Determinação de HbA1c por CLAE: interferência de variantes de hemoglobinas S e C e alta concentração de HbF 

  Menezes, Maria das Graças Santos; Adorno, Elisângela Vitória; Barbosa, Cynara Gomes; Gonçalves, Marilda de Souza; Couto, Fábio David; Santos Junior, Lázaro Silveira; Couto, Ricardo David (Brasil, 2012)

  INTRODUÇÃO: O diabetes mellitus (DM) é considerado um problema importante de saúde pública; possui prevalência elevada e nos últimos anos observa-se aumento progressivo na sua incidência. OBJETIVO: verificar possíveis ...
• Increased concentrations of IL-18 and uric acid in sickle cell anemia: Contribution of hemolysis, endothelial activation and the inflammasome_7 

  Goncalves, Marilda S.; Cerqueira, Bruno A. V.; Vilas Boas, Wendell; Zanette, Angela Maria Dias; Reis, Mitermayer Galvão dos (2011)

  Sickle cell anemia (SCA) is a common, severe monogenetic disorder characterized by chronic hemolysis, frequent infections, a chronic inflammatory state and recurrent occlusions of the microcirculation, resulting in painful ...
• Schistosoma Antigens Downmodulate the in vitro Inflammatory Response in Individuals Infected with Human T Cell Lymphotropic Virus Type 1 

  Lima, Luciane Mota; Santos, Silvane Maria Braga; Oliveira, Ricardo Riccio; Cardoso, Luciana Santos; Oliveira, Sérgio Costa; Góes, Alfredo Miranda; Loukas, Alex; Carvalho Filho, Edgar Marcelino de; Araujo, Maria Ilma Andrade Santos (2013)

  Human T cell lymphotropic virus type 1 (HTLV-1) is the causal agent of HTLV-1-associated myelopathy/tropical spastic paraparesis (HAM/TSP). While the immune response to HTLV-1 infection is polarized to the Th1-type, chronic ...
• Clinical outcome of pneumococcal meningitis during the emergence of pencillin-resistant Streptococcus pneumoniae: an observational study 

  Reis, Joice N.; Gouveia, Edilane L.; Flannery, Brendan; Cordeiro, Soraia Machado; Lima, Josilene B. T.; Pinheiro, Ricardo M.; Salgado, Kátia; Mascarenhas, Ana Veronica; Carvalho, M. Gloria; Beall, Bernard W.; Reis, Mitermayer Galvão dos; Ko, Albert I. (Brasil, 2011)

  Background Prior to the availability of generic third-generation cephalosporins, penicillins were widely used for treatment of pneumococcal meningitis in developing countries despite concerns about rising levels of penicillin ...
• Hookworm and threadworm infections and their association with hemoglobin and eosinophil concentrations in residents of Salvador-Bahia, Brazil 

  Santos, Fred Luciano Neves; Souza, Alina Maria Gonzaga Carlos de; Soares, Neci Matos (Brasil, 2013)

  Parasitic infections are responsible for substantial mortality and morbidity worldwide. In most healthy individuals, little overt pathology is observed during infection with S. stercoralis. However, the symptoms in advanced ...
• Participation of nitric oxide pathway in the relaxation response induced by E-cinnamaldehyde oxime in superior mesenteric artery isolated from rats 

  Veras, Robson Cavalcante; Rodrigues, Karoline Gomes; Fernandes, Maria do Carmo de Alustau; Gonçalves, Islania Giselia Albuquerque; Barros, André Luis Branco de; Alves, Ricardo José; Nakao, Lia Sumie; Braga, Valdir de Andrade; Vasconcelos, Darizy Flavia Silva Amorim de; Medeiros, Isac Almeida de (2013)

  For many years, nitric oxide (NO) has been studied as an important mediator in the control of vascular tone. Endothelial deficiencies that diminish NO production can result in the development of several future cardiovascular ...
• 2D chemometric studies of a series of azole derivatives active against fluconazole-resistant Cryptococcus gattii 

  Freitas, Humberto F.; Barros, Tânia Fraga; Castilho, Marcelo Santos (Brasil, 2013)

  Despite advances in the development of antifungal drugs,there has been an upsurge of cryptococosis infections that poorly respond to fluconazole (first choice drug). Hence,it is paramount to investigate the chemical ...
• Enhancement of Experimental Cutaneous Leishmaniasis by Leishmania Molecules Is Dependent on Interleukin-4, Serine Protease/Esterase Activity, and Parasite and Host Genetic Backgrounds 

  Teixeira, Márcia Cristina Aquino; Silva, Virgínia M. G.; Larangeira, Daniela Farias; Oliveira, Pablo R. S.; Sampaio, Romina B.; Suzart, Paula; Nihei, Jorge S.; Mengel, José O.; Santos, Washington Luis Conrado dos; Carvalho, Lain Carlos Pontes de (2011)

  Most inbred strains of mice, like the BALB/c strain, are susceptible to Leishmania amazonensis infections and resistant to Leishmania braziliensis infections. This parasite-related difference could result from the activity ...

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