Acetylcholinesterase activity of alkaloids from the leaves of Waltheria brachypetala

Lima, Murilo M. C.; López, Jorge A.; David, Jorge Mauricio; Silva, Eliezer P.; Giulietti, Ana M.; Queiroz, Luciano Paganucci de; David, Juceni Pereira de Lima

Acetylcholinesterase activity of alkaloids from the leaves of Waltheria brachypetala

Lima, Murilo M. C.; López, Jorge A.; David, Jorge Mauricio; Silva, Eliezer P.; Giulietti, Ana M.; Queiroz, Luciano Paganucci de; David, Juceni Pereira de Lima

URI: http://repositorio.ufba.br/ri/handle/ri/13413

Date: 2009

Abstract:

Chemical investigation of the leaves of Waltheria brachypetala Turks (Sterculiaceae) resulted in the isolation of quinolinone alkaloids, waltherione-A, waltherione-B (N-methylwaltherione-A), 8-methoxyflindersine, and the cyclic peptide alkaloid waltherine. The inhibition of activity of acetylcholinesterase (AChE) by the alkaloids was evaluated. Waltherione-A, waltherione-B and waltherine showed significant activity.