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metadata.dc.type: | Artigo de Periódico |
Title: | Effect of third ventricle administration of L-694,247, a selective 5-HT1(D) receptor agonist, on water intake in rats |
Other Titles: | Pharmacology Biochemistry and Behavior |
Authors: | Silva, E. de Castro e Sarmento, Clarissa Nascimento, T. A. Luz, C. P. Soares, T. Marinho, C. A. Cunha, M. Bulcão, C. Oliveira, I. R. de Fregoneze, J. B. |
metadata.dc.creator: | Silva, E. de Castro e Sarmento, Clarissa Nascimento, T. A. Luz, C. P. Soares, T. Marinho, C. A. Cunha, M. Bulcão, C. Oliveira, I. R. de Fregoneze, J. B. |
Abstract: | DE CASTRO-E-SILVA, E., C. SARMENTO, T. A. NASCIMENTO, C. P. LUZ, T. SOARES, C. A. MARINHO, M. CUNHA, C. BULCÃO, I. R. DE OLIVEIRA AND J. B. FREGONEZE. Effect of third ventricle administration of L-694,247, a selective 5-HT1D receptor agonist, on water intake in rats. PHARMACOL BIOCHEM BEHAV 57[4]749–754, 1997.—L-694,247, a selective 5-HT1D receptor agonist, injected directly into the third ventricle (2.5, 5.0, and 10.0 μg/rat) of dehydrated rats induced a dose-dependent partial blockade of water intake. Injected in this way, the compound abolishes drinking behavior induced by third ventricle administration of carbachol (2 μg/rat), angiotensin II (5 ng/rat), and isoproterenol (40 μg/rat). In addition, intraventricular injections of L-694,247 did not modify water intake in normohydrated rats. The effects of L-694,247 are due to a specific interaction with 5-HT1D receptors, because its inhibitory effect on water intake in dehydrated rats is blocked by the previous administration of a 5-HT1D antagonist, GR 127935 (5 μg/rat), directly into the third ventricle. It is concluded that central 5-HT1D receptor activation disrupts the functional integrity of central pathways related to drinking behavior. |
Keywords: | 5-HT1D receptors Serotonin Angiotensin II Adrenoceptors Cholinergic receptors Drinking behavior |
URI: | http://www.repositorio.ufba.br/ri/handle/ri/8320 |
Issue Date: | 1997 |
Appears in Collections: | Artigo Publicado em Periódico (ICS) |
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