https://repositorio.ufba.br/handle/ri/7675
Tipo: | Artigo de Periódico |
Título: | HTLV-1 decreases Th2 type of immune response in patients with strongyloidiasis |
Título(s) alternativo(s): | Parasite Immunology |
Autor(es): | Porto, Maria Aurélia da Fonseca Neva, Franklin A. Bittencourt, Helito Lisboa, Waldir Thompson, Robert Alcântara, Luiz Carlos Júnior Carvalho Filho, Edgar Marcelino de |
Autor(es): | Porto, Maria Aurélia da Fonseca Neva, Franklin A. Bittencourt, Helito Lisboa, Waldir Thompson, Robert Alcântara, Luiz Carlos Júnior Carvalho Filho, Edgar Marcelino de |
Abstract: | Eosinophils, immunoglobilin (Ig)E and cytokines have important roles in defence mechanisms against helminths. In this study, the influence of HTLV-1 infection, characterized by a Th1 type of immune response, was evaluated on the cytokine pattern and parasitic specific IgE response in patients with strongyloidiasis. Patients were divided into four groups: strongyloidiasis without HTLV-1 infection, strongyloidiasis with HTLV-1, HTLV-1 without strongyloidiasis and controls without either helminth infection or HTLV-1. The cytokine profile was determined in supernatants of mononuclear cells stimulated with Strongyloides stercoralis crude antigen and the parasite specific IgE was measured by ELISA. Patients coinfected with HTLV-1 had higher levels of interfron (IFN)-γ and interleukin (IL)-10 (P < 0·05) and lower levels of IL-5 and IgE (P < 0·05) than patients with strongyloidiasis without HTLV-1. There was an inverse relationship between IFN-γ and IL-5 (P = 0·01; rs = − 0·37) and between IFN-γ and parasite specific IgE (P = 0·01; rs = − 0·39), and a direct relationship between IFN-γ and IL-10 (P = 0·04; rs = 0·35). These data show that coinfection with HTLV-1 decreases IL-5 and IgE responses in patients with strongyloidiasis consistent with a relative switch from Th2 to Th1 response. Immunological responses such as these are important in the control of this helminthic infection. |
Palavras-chave: | HTLV-1 strongyloidiasis IgE S. stercoralis |
URI: | http://www.repositorio.ufba.br/ri/handle/ri/7675 |
Data do documento: | 2001 |
Aparece nas coleções: | Artigo Publicado em Periódico (ICS) |
Arquivo | Descrição | Tamanho | Formato | |
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j.1365-3024.2001.00407.pdf Restricted Access | 92,94 kB | Adobe PDF | Visualizar/Abrir Solicitar uma cópia |
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