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Campo DC | Valor | Idioma |
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dc.contributor.author | Porto, Maria Aurélia da Fonseca | - |
dc.contributor.author | Neva, Franklin A. | - |
dc.contributor.author | Bittencourt, Helito | - |
dc.contributor.author | Lisboa, Waldir | - |
dc.contributor.author | Thompson, Robert | - |
dc.contributor.author | Alcântara, Luiz Carlos Júnior | - |
dc.contributor.author | Carvalho Filho, Edgar Marcelino de | - |
dc.creator | Porto, Maria Aurélia da Fonseca | - |
dc.creator | Neva, Franklin A. | - |
dc.creator | Bittencourt, Helito | - |
dc.creator | Lisboa, Waldir | - |
dc.creator | Thompson, Robert | - |
dc.creator | Alcântara, Luiz Carlos Júnior | - |
dc.creator | Carvalho Filho, Edgar Marcelino de | - |
dc.date.accessioned | 2012-12-19T17:29:27Z | - |
dc.date.issued | 2001 | - |
dc.identifier.issn | 0141-9838 | - |
dc.identifier.uri | http://www.repositorio.ufba.br/ri/handle/ri/7675 | - |
dc.description | Texto completo: acesso restrito. p. 503–507 | pt_BR |
dc.description.abstract | Eosinophils, immunoglobilin (Ig)E and cytokines have important roles in defence mechanisms against helminths. In this study, the influence of HTLV-1 infection, characterized by a Th1 type of immune response, was evaluated on the cytokine pattern and parasitic specific IgE response in patients with strongyloidiasis. Patients were divided into four groups: strongyloidiasis without HTLV-1 infection, strongyloidiasis with HTLV-1, HTLV-1 without strongyloidiasis and controls without either helminth infection or HTLV-1. The cytokine profile was determined in supernatants of mononuclear cells stimulated with Strongyloides stercoralis crude antigen and the parasite specific IgE was measured by ELISA. Patients coinfected with HTLV-1 had higher levels of interfron (IFN)-γ and interleukin (IL)-10 (P < 0·05) and lower levels of IL-5 and IgE (P < 0·05) than patients with strongyloidiasis without HTLV-1. There was an inverse relationship between IFN-γ and IL-5 (P = 0·01; rs = − 0·37) and between IFN-γ and parasite specific IgE (P = 0·01; rs = − 0·39), and a direct relationship between IFN-γ and IL-10 (P = 0·04; rs = 0·35). These data show that coinfection with HTLV-1 decreases IL-5 and IgE responses in patients with strongyloidiasis consistent with a relative switch from Th2 to Th1 response. Immunological responses such as these are important in the control of this helminthic infection. | pt_BR |
dc.language.iso | en | pt_BR |
dc.source | http://dx.doi.org/10.1046/j.1365-3024.2001.00407.x | pt_BR |
dc.subject | HTLV-1 | pt_BR |
dc.subject | strongyloidiasis | pt_BR |
dc.subject | IgE | pt_BR |
dc.subject | S. stercoralis | pt_BR |
dc.title | HTLV-1 decreases Th2 type of immune response in patients with strongyloidiasis | pt_BR |
dc.title.alternative | Parasite Immunology | pt_BR |
dc.type | Artigo de Periódico | pt_BR |
dc.identifier.number | v. 23, n. 9 | pt_BR |
dc.embargo.liftdate | 10000-01-01 | - |
Aparece nas coleções: | Artigo Publicado em Periódico (ICS) |
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