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https://repositorio.ufba.br/handle/ri/6699
metadata.dc.type: | Artigo de Periódico |
Title: | Smooth muscle antibodies and cryoglobulinemia are associated with advanced liver fibrosis in Brazilian hepatitis C virus carriers |
Other Titles: | Brazilian Journal of Infectious Diseases |
Authors: | Andrade, Luis Jesuino de Oliveira Melo, Paulo Roberto Santana de Atta, Ajax Mercês Atta, Maria Luiza Brito de Sousa Jesus, Larissa Santana de Sousa, Gabriel Menezes de Silva, Carolina Alves Costa Paraná, Raymundo |
metadata.dc.creator: | Andrade, Luis Jesuino de Oliveira Melo, Paulo Roberto Santana de Atta, Ajax Mercês Atta, Maria Luiza Brito de Sousa Jesus, Larissa Santana de Sousa, Gabriel Menezes de Silva, Carolina Alves Costa Paraná, Raymundo |
Abstract: | Cryoglobulinemia and non-organ-specific-autoantibody are biomarkers of autoimmunity of the chronic infection caused by hepatitis C virus (HCV). In this work, we report the association between the presence of smooth muscle antibodies (SMA) and cryoglobulinemia and chronic liver disease in HCV carriers. Sixty-five untreated HCV patients, 38 women and 27 men were included in this study. Cryoglobulinemia was tested by cryoprecipitation, SMA by indirect fluorescent antibody test, and liver fibrosis and hepatocellular inflammation activity was investigated by histology of liver biopsy using the METAVIR score. The prevalence of SMA in the patients was 33.8% and cryoglobulinemia was demonstrated in 36.9% patients. Cryoglobulinemia and SMA seropositivity was associated with advanced fibrosis (p < 0.05). The presence of SMA and cryoglobulinemia was not associated with hepatocellular inflammation activity, age, carrier gender or HCV genotype. We concluded that liver biopsy should be recommended for HCV carriers that are seropositive for SMA or cryoglobulinemia. |
Keywords: | Hepatitis C Muscle Smooth Antibody specificity Cryoglobulins Liver diseases |
Publisher: | The Brazilian Journal of Infectious Diseases and Contexto Publishing |
URI: | http://www.repositorio.ufba.br/ri/handle/ri/6699 |
Issue Date: | Jan-2011 |
Appears in Collections: | Artigo Publicado em Periódico (Faculdade de Medicina) |
Files in This Item:
File | Description | Size | Format | |
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Andrade, Luis Jesuino de Oliveira (2).pdf | 742,18 kB | Adobe PDF | View/Open |
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