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https://repositorio.ufba.br/handle/ri/6491| metadata.dc.type: | Artigo de Periódico |
| Title: | Astroglial cells in primary culture: a valid model to study Neospora caninum infection in the CNS |
| Other Titles: | Veterinary Immunology and Immunopathology |
| Authors: | Pinheiro, A. M. Costa, Silvia Lima Freire, S. M. Almeida, Maria Angela Ornelas de Tardy, Marcienne Bloch El-Bachá, Ramon dos Santos Costa, Maria de Fátima Dias |
| metadata.dc.creator: | Pinheiro, A. M. Costa, Silvia Lima Freire, S. M. Almeida, Maria Angela Ornelas de Tardy, Marcienne Bloch El-Bachá, Ramon dos Santos Costa, Maria de Fátima Dias |
| Abstract: | The protozoan Neospora caninum has a veterinary importance because it causes abortion in cattle and neuromuscular alterations in dogs. We infected rat astrocytes, in vitro, with different concentrations of N. caninum. Astrocytes responded to infection by producing the pro-inflammatory cytokine TNF-α and the neurotoxic—free radical NO, 24 and 72 h post-infection. These data suggest that astrocytes, which are essential for brain function, are targets for the parasite and this represents a practical and valid model to study the effects of N. caninum on the CNS. |
| Keywords: | Neospora caninum Astrocytes Model Infection TNF-α and NO |
| Publisher: | Veterinary Immunology and Immunopathology |
| URI: | http://www.repositorio.ufba.br/ri/handle/ri/6491 |
| Issue Date: | 2006 |
| Appears in Collections: | Artigo Publicado em Periódico (EMV) |
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