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metadata.dc.type: | Artigo de Periódico |
Title: | Acute HIV infection with rapid progression to AIDS |
Other Titles: | Brazilian Journal of Infectious Diseases |
Authors: | Silva, Marcio de Oliveira Bastos, Milena de Carvalho Martins Netto, Eduardo Gouvea, Nancy Alves de Lima Torres, Alex José Leite Kallas, Esper Watkins, David I. Altfeld, Marcus Brites, Carlos |
metadata.dc.creator: | Silva, Marcio de Oliveira Bastos, Milena de Carvalho Martins Netto, Eduardo Gouvea, Nancy Alves de Lima Torres, Alex José Leite Kallas, Esper Watkins, David I. Altfeld, Marcus Brites, Carlos |
Abstract: | Acute HIV infection is rarely recognized as the signs and symptoms are normally unspecific and can persist for days or weeks. The normal HIV course is characterized by a progressive loss of CD4+ cells, which normally leads to severe immunodeficiency after a variable time interval. The mean time from initial infection to development of clinical AIDS is approximately 8-10 years, but it is variable among individuals and depends on a complex interaction between virus and host. Here we describe an extraordinary case of a man who developed Pneumocisits jiroveci pneumonia within one month after sexual exposure to HIV-1, and then presented with 3 consecutive CD4 counts bellow 200 cells/mm3 within 3 months, with no other opportunistic disease. Although antiretroviral therapy (AZT+3TC+ATZ/r) was started, with full adherence of the patient, and genotyping indicating no primary antiretroviral resistance mutations, he required more than six months to have a CD4 restoration to levels above 200 cells/mm3 and 10 months to HIV-RNA to become undetectable. |
Keywords: | HIV acute infection progression AIDS |
URI: | http://www.repositorio.ufba.br/ri/handle/ri/5790 |
Issue Date: | 2010 |
Appears in Collections: | Artigo Publicado em Periódico (Faculdade de Medicina) |
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__www.scielo.br_pdf_bjid_v14n3_v14n3a16.pdf Restricted Access | 383,21 kB | Adobe PDF | View/Open Request a copy |
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