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metadata.dc.type: | Artigo de Periódico |
Title: | Human major histocompatibility complex and thyroid dysfunction in hepatitis C carries |
Other Titles: | Revista de Ciências Médicas e Biológicas |
Authors: | Andrade, Luis Jesuino de Oliveira Melo, Paulo Roberto Santana de França, Larissa Santos França, Luciana Santos Malta, Ana Micheline Andrade Paraná, Raymundo |
metadata.dc.creator: | Andrade, Luis Jesuino de Oliveira Melo, Paulo Roberto Santana de França, Larissa Santos França, Luciana Santos Malta, Ana Micheline Andrade Paraná, Raymundo |
Abstract: | Abstract The major histocompatibility complex (MHC) is a multigenice family of receptors which are crucial in antigen presentation, mediation, and initiation of the cellular immune response. An association exists between certain MHC polymorphisms and autoimmune thyroid disease in animals and humans. Hepatitis C virus (HCV) infection the treatment of hepatitis C with interferon- (IFN- )have been shown to be associated with increased incidence of thyroid dysfunction. IFN- has been the basis for the treatment of HCV infection identified as an immunomodulatory cytokine that induces T-lymphocyte activation and expression of MHC molecules. It becomes evident therefore that the MHC- class I and MHC- class II antigens are central to the host immune response and thus are ideal candidate genes to investigate for associations with HCV infection. Autoimmune thyroid diseases are characterized by increased, rather than decreased expression, of MHC- class II antigen. Furthermore, work in animals suggests that the increased production of thyroid antibody and expression of MHC- class I and MHC- class II antigen are associated. This study will approach the relation between MHC and thyroid dysfunction in HCV infection carries. |
Keywords: | Complexo de histocompatibilidade maior Hepatite C Interferon-alfa Disfunção da tireóide Auto-imunidade. |
metadata.dc.publisher.country: | Brasil |
Publisher: | Instituto de Ciências da Saúde/ Universidade Federal da Bahia |
Citation: | R. Ci. med. biol., Salvador, v.10, n.2, p.179-186, mai./ago. 2011 |
metadata.dc.rights: | Acesso Aberto |
URI: | http://repositorio.ufba.br/ri/handle/ri/22806 |
Issue Date: | May-2011 |
Appears in Collections: | Artigo Publicado em Periódico (PPGPIOS) |
Files in This Item:
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13_v.10_2.pdf | 784,95 kB | Adobe PDF | View/Open |
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