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metadata.dc.type: | Artigo de Periódico |
Title: | Identification of novel recombinants of hepatitis B virus genotypes F and G in human immunodeficiency virus-positive patients from Argentina and Brazil |
Other Titles: | Journal of General Virology |
Authors: | Araujo, Natália Motta de Araujo, Oscar Rafael Carmo Silva, Edinete Melo da Villella-Nogueira, Cristiane Alves Nabuco, Letícia Cancella Paraná, Raymundo Bessone, Fernando Gomes, Selma de Andrade Trepo, Christian Kay, Alan Campbell |
metadata.dc.creator: | Araujo, Natália Motta de Araujo, Oscar Rafael Carmo Silva, Edinete Melo da Villella-Nogueira, Cristiane Alves Nabuco, Letícia Cancella Paraná, Raymundo Bessone, Fernando Gomes, Selma de Andrade Trepo, Christian Kay, Alan Campbell |
Abstract: | Hepatitis B virus (HBV) genotype G (HBV/G) infection is almost always detected along with a co-infecting HBV strain that can supply HBeAg, typically HBV/A2. In this study we describe, in two human immunodeficiency virus (HIV)-positive patients from Argentina and Brazil, the first report of HBV/G infection in Argentina and co-circulation of HBV/G, HBV/F and G/F recombinants in the American continent. HBV isolates carrying the 36 bp insertion of HBV/G were the most prevalent in both patients, with >99 % of colonies hybridizing to a probe specific for this insertion. Phylogenetic analyses of full-length genomes and precore/core fragments revealed that F4 and F1b were the co-infecting subgenotypes in the Brazilian and Argentinian patients, respectively. Bootscanning analysis provided evidence of recombination in several clones from both patients, with recombination breakpoints located mainly at the precore/core region. These data should encourage further investigations on the clinical implications of HBV/G recombinants in HBV/HIV co-infected patients. |
Keywords: | Hepatitis B Hepatitis B virus HBeAg AIDS Serodiagnosis |
metadata.dc.rights: | Acesso Aberto |
URI: | http://repositorio.ufba.br/ri/handle/ri/17666 |
Issue Date: | 2013 |
Appears in Collections: | Artigo Publicado em Periódico (Faculdade de Medicina) |
Files in This Item:
File | Description | Size | Format | |
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Natalia M. Araujo.pdf | 875,63 kB | Adobe PDF | View/Open |
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