Please use this identifier to cite or link to this item:
https://repositorio.ufba.br/handle/ri/17522
metadata.dc.type: | Artigo de Periódico |
Title: | Lesion Size Correlates with Leishmania Antigen-Stimulated TNF-Levels in Human Cutaneous Leishmaniasis |
Other Titles: | American Journal of Tropical Medicine and Hygiene |
Authors: | Oliveira, Luiz Fabiano Borges Báfica, Andre Luiz Barbosa Rosato, Andréa Bomura Favali, Cecilia Beatriz Fiuza Costa, Jackson Mauricio Lopes Café, Virginia Barral-Netto, Manoel Barral, Aldina Maria Prado |
metadata.dc.creator: | Oliveira, Luiz Fabiano Borges Báfica, Andre Luiz Barbosa Rosato, Andréa Bomura Favali, Cecilia Beatriz Fiuza Costa, Jackson Mauricio Lopes Café, Virginia Barral-Netto, Manoel Barral, Aldina Maria Prado |
Abstract: | Cutaneous leishmaniasis (CL) is a worldwide disease endemic in several regions of the globe. The hallmark of CL is skin ulcers likely driven by efforts of the immune system to control Leishmania growth. Cytokines, such as tumor necrosis factor (TNF) and interferon-gamma can control disease progression in animal models. Nevertheless, the impact of these cytokines in CL ulcer outcome is not well established in humans. In this study, 96 CL patients from an endemic area of Leishmania braziliensis were enrolled for a follow-up study that consisted of clinical and immunological evaluations in a 2-year period. Statistical analysis revealed that healing time (P = 0.029), age (P = 0.002), and TNF levels (P = 0.0002) positively correlate with ulcer size at the time of the first clinical evaluation. Our findings suggest that ulcer size correlates with healing time and TNF levels support the use of TNF inhibitors combined with standard therapy to improve healing in CL patients with severe lesions. |
Keywords: | Leishmania Cytokines Lymphotoxin-alpha |
metadata.dc.publisher.country: | Brasil |
metadata.dc.rights: | Acesso Aberto |
URI: | http://repositorio.ufba.br/ri/handle/ri/17522 |
Issue Date: | 2011 |
Appears in Collections: | Artigo Publicado em Periódico (Faculdade de Medicina) |
Files in This Item:
File | Description | Size | Format | |
---|---|---|---|---|
Fabiano Oliveira.pdf | 471,06 kB | Adobe PDF | View/Open |
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.