Skip navigation
Universidade Federal da Bahia |
Repositório Institucional da UFBA
Use este identificador para citar ou linkar para este item: https://repositorio.ufba.br/handle/ri/16689
Tipo: Artigo de Periódico
Título: Evidence for the Involvement of Descending Pain-Inhibitory Mechanisms in the Antinociceptive Effect of Hecogenin Acetate
Título(s) alternativo(s): Journal of Natural Products
Autor(es): Gama, Kelly Barbosa
Quintans, Jullyana de Souza Siqueira
Antoniolli, Ângelo Roberto
Quintans Júnior, Lucindo José
Santana, Wagno Alcântara de
Branco, Alexsandro
Soares, Milena Botelho Pereira
Villarreal, Cristiane Flora
Autor(es): Gama, Kelly Barbosa
Quintans, Jullyana de Souza Siqueira
Antoniolli, Ângelo Roberto
Quintans Júnior, Lucindo José
Santana, Wagno Alcântara de
Branco, Alexsandro
Soares, Milena Botelho Pereira
Villarreal, Cristiane Flora
Abstract: Hecogenin is a sapogenin present in the leaves of species from the Agave genus, with a wide spectrum of reported pharmacological activities. The present study was undertaken to evaluate whether hecogenin acetate (1) has antinociceptive properties and to determine its mechanism of action. The nociceptive threshold was evaluated using the tail flick test in mice. Mice motor performance was evaluated in a Rotarod test. By using Fos expression as a marker of neural activation, the involvement of the periaqueductal gray in 1-induced antinociception was evaluated. Intraperitoneal administration of 1 (5–40 mg/kg) produced a dose-dependent increase in the tail flick latency time compared to vehicle-treated group (p < 0.01). Mice treated with 1 (40 mg/kg) did not show motor performance alterations. The antinociception of 1 (40 mg/kg) was prevented by naloxone (nonselective opioid receptor antagonist; 5 mg/kg), CTOP (μ-opioid receptor antagonist; 1 mg/kg), nor-BNI (κ-opioid receptor antagonist; 0.5 mg/kg), naltrindole (δ-opioid receptor antagonist; 3 mg/kg), or glibenclamide (ATP-sensitive K+ channel blocker; 2 mg/kg). Systemic administration of 1 (5–40 mg/kg) increased the number of Fos positive cells in the periaqueductal gray. The present study has demonstrated for the first time that 1 produces consistent antinociception mediated by opioid receptors and endogenous analgesic mechanisms.
Tipo de Acesso: Acesso Aberto
URI: http://repositorio.ufba.br/ri/handle/ri/16689
Data do documento: 2013
Aparece nas coleções:Artigo Publicado em Periódico (FAR)

Arquivos associados a este item:
Arquivo Descrição TamanhoFormato 
Kelly Barbosa Gama.pdf608,74 kBAdobe PDFVisualizar/Abrir
Mostrar registro completo do item Visualizar estatísticas


Os itens no repositório estão protegidos por copyright, com todos os direitos reservados, salvo quando é indicado o contrário.