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Use este identificador para citar ou linkar para este item: https://repositorio.ufba.br/handle/ri/16689
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dc.contributor.authorGama, Kelly Barbosa-
dc.contributor.authorQuintans, Jullyana de Souza Siqueira-
dc.contributor.authorAntoniolli, Ângelo Roberto-
dc.contributor.authorQuintans Júnior, Lucindo José-
dc.contributor.authorSantana, Wagno Alcântara de-
dc.contributor.authorBranco, Alexsandro-
dc.contributor.authorSoares, Milena Botelho Pereira-
dc.contributor.authorVillarreal, Cristiane Flora-
dc.creatorGama, Kelly Barbosa-
dc.creatorQuintans, Jullyana de Souza Siqueira-
dc.creatorAntoniolli, Ângelo Roberto-
dc.creatorQuintans Júnior, Lucindo José-
dc.creatorSantana, Wagno Alcântara de-
dc.creatorBranco, Alexsandro-
dc.creatorSoares, Milena Botelho Pereira-
dc.creatorVillarreal, Cristiane Flora-
dc.date.accessioned2014-12-01T20:40:03Z-
dc.date.issued2013-
dc.identifier.issn0163-3864-
dc.identifier.urihttp://repositorio.ufba.br/ri/handle/ri/16689-
dc.descriptionTexto completo: acesso restrito. p. 559−563pt_BR
dc.description.abstractHecogenin is a sapogenin present in the leaves of species from the Agave genus, with a wide spectrum of reported pharmacological activities. The present study was undertaken to evaluate whether hecogenin acetate (1) has antinociceptive properties and to determine its mechanism of action. The nociceptive threshold was evaluated using the tail flick test in mice. Mice motor performance was evaluated in a Rotarod test. By using Fos expression as a marker of neural activation, the involvement of the periaqueductal gray in 1-induced antinociception was evaluated. Intraperitoneal administration of 1 (5–40 mg/kg) produced a dose-dependent increase in the tail flick latency time compared to vehicle-treated group (p < 0.01). Mice treated with 1 (40 mg/kg) did not show motor performance alterations. The antinociception of 1 (40 mg/kg) was prevented by naloxone (nonselective opioid receptor antagonist; 5 mg/kg), CTOP (μ-opioid receptor antagonist; 1 mg/kg), nor-BNI (κ-opioid receptor antagonist; 0.5 mg/kg), naltrindole (δ-opioid receptor antagonist; 3 mg/kg), or glibenclamide (ATP-sensitive K+ channel blocker; 2 mg/kg). Systemic administration of 1 (5–40 mg/kg) increased the number of Fos positive cells in the periaqueductal gray. The present study has demonstrated for the first time that 1 produces consistent antinociception mediated by opioid receptors and endogenous analgesic mechanisms.pt_BR
dc.language.isoenpt_BR
dc.rightsAcesso Abertopt_BR
dc.sourcehttp://dx.doi.org/ 10.1021/np3007342pt_BR
dc.titleEvidence for the Involvement of Descending Pain-Inhibitory Mechanisms in the Antinociceptive Effect of Hecogenin Acetatept_BR
dc.title.alternativeJournal of Natural Productspt_BR
dc.typeArtigo de Periódicopt_BR
dc.identifier.numberv. 76, n. 4pt_BR
dc.embargo.liftdate10000-01-01-
Aparece nas coleções:Artigo Publicado em Periódico (FAR)

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