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metadata.dc.type: | Artigo de Periódico |
Title: | Failure of early treatment of Cutaneous Leishmaniasis in preventing the development of an ulcer |
Other Titles: | Clinical Infectious Diseases |
Authors: | Machado, Paulo Roberto Lima Araújo, Cibele Silva, Andréa T. da Almeida, Roque Pacheco de D'Oliveira Junior, Argemiro Bittencourt, Achilea Candida Lisboa Carvalho Filho, Edgar Marcelino de |
metadata.dc.creator: | Machado, Paulo Roberto Lima Araújo, Cibele Silva, Andréa T. da Almeida, Roque Pacheco de D'Oliveira Junior, Argemiro Bittencourt, Achilea Candida Lisboa Carvalho Filho, Edgar Marcelino de |
Abstract: | The clinical characteristics and treatment outcome were determined for 26 patients who presented with early-stage cutaneous leishmaniasis. Illness duration ranged from 8 to 20 days, and the commonest clinical presentation was the presence of a papule with small central crust on a lower extremity. Prominent regional adenopathy was found in 22 (85%) of 26 patients. The results of an intradermal skin test for Leishmania were positive for 96% of those patients, and results of serologic testing were positive for 61% of patients tested. Ten (46%) of 22 patients for whom follow-up data were available developed enlargement and ulceration of the lesion despite early antimony therapy and required additional courses of treatment. Histopathological studies of samples from the lesions of 3 patients showed vasculitis. These data show that early therapy for cutaneous leishmaniasis does not prevent the development of an ulcer in one-half of patients. This unfavorable outcome underlines the relevance of local exacerbated inflammatory and immune response in the pathogenesis of the disease. |
Keywords: | Leishmaniasis, Cutaneous Ulcer |
metadata.dc.rights: | Acesso Aberto |
URI: | http://repositorio.ufba.br/ri/handle/ri/16641 |
Issue Date: | 2002 |
Appears in Collections: | Artigo Publicado em Periódico (Faculdade de Medicina) |
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